Abstract
Alzheimer’s disease (AD) is currently one of the most studied neurodegenerative disorders in humans. First reported in 1907, the disease has a familial form which represents approximately 5% of cases, while the remaining, sporadic cases are of multifactorial etiology. The disease progression of the latter form has specific pathological and functional characteristics, which have unknown etiology. Several authors have proposed a viral etiology for AD, while others implicate many neurotropic infectious agents. This review compares research findings regarding pathways and effects of neuropathological viruses with the pathways and effects involved in the progression of AD. The similarities are striking and provide a compelling argument for a pathogen-based etiology of AD.
Keywords: Alzheimer’s disease, beta amyloid, cell cycle reentry, herpes simplex virus, HSV1, tau pathology.
Current Alzheimer Research
Title:Connections Between Herpes Simplex Virus Type 1 and Alzheimer's Disease Pathogenesis
Volume: 13 Issue: 9
Author(s): James McNamara and Teresa Ann Murray
Affiliation:
Keywords: Alzheimer’s disease, beta amyloid, cell cycle reentry, herpes simplex virus, HSV1, tau pathology.
Abstract: Alzheimer’s disease (AD) is currently one of the most studied neurodegenerative disorders in humans. First reported in 1907, the disease has a familial form which represents approximately 5% of cases, while the remaining, sporadic cases are of multifactorial etiology. The disease progression of the latter form has specific pathological and functional characteristics, which have unknown etiology. Several authors have proposed a viral etiology for AD, while others implicate many neurotropic infectious agents. This review compares research findings regarding pathways and effects of neuropathological viruses with the pathways and effects involved in the progression of AD. The similarities are striking and provide a compelling argument for a pathogen-based etiology of AD.
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Cite this article as:
McNamara James and Murray Ann Teresa, Connections Between Herpes Simplex Virus Type 1 and Alzheimer's Disease Pathogenesis, Current Alzheimer Research 2016; 13 (9) . https://dx.doi.org/10.2174/1567205013666160314150136
DOI https://dx.doi.org/10.2174/1567205013666160314150136 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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