Abstract
The use of nanodevices to transport active compounds like small-molecular drugs, peptides, or genes found an increased attention throughout the different fields of natural sciences. Moreover, recent research trends are focused on the employment of smart nanocarriers able to react on certain internal or external applied stimuli, in order to achieve temporal and site-specific drugs/gene release. In contrast to traditional biodegradable nanocarriers that slowly release drugs inside the cells, these smart nanosystems are able to quickly release or even dump drugs in response to a specific biological signal in the target cancer cells such lower pH, high redox potential or over expression of enzymes or to external stimuli such as temperature, light, ultrasounds and magnetic field. This review gives a brief overview about some types of stimuli-responsive nanocarriers, with the main focus on magnetic fieldresponsive devices obtained from natural polymers. The concept of magnetic field-sensitive nanocarriers, their advantages and disadvantages, the methods of preparation and applications in various fields of drug delivery will be explored, giving an exhaustive collection of the findings of recent investigations.
Keywords: Nanocarriers, stimuli-responsivity, natural polymers, magnetic nanoparticles.
Current Pharmaceutical Design
Title:Advances on Magnetic Nanocarriers Based on Natural Polymers
Volume: 22 Issue: 22
Author(s): Rita Muzzalupo and Lorena Tavano
Affiliation:
Keywords: Nanocarriers, stimuli-responsivity, natural polymers, magnetic nanoparticles.
Abstract: The use of nanodevices to transport active compounds like small-molecular drugs, peptides, or genes found an increased attention throughout the different fields of natural sciences. Moreover, recent research trends are focused on the employment of smart nanocarriers able to react on certain internal or external applied stimuli, in order to achieve temporal and site-specific drugs/gene release. In contrast to traditional biodegradable nanocarriers that slowly release drugs inside the cells, these smart nanosystems are able to quickly release or even dump drugs in response to a specific biological signal in the target cancer cells such lower pH, high redox potential or over expression of enzymes or to external stimuli such as temperature, light, ultrasounds and magnetic field. This review gives a brief overview about some types of stimuli-responsive nanocarriers, with the main focus on magnetic fieldresponsive devices obtained from natural polymers. The concept of magnetic field-sensitive nanocarriers, their advantages and disadvantages, the methods of preparation and applications in various fields of drug delivery will be explored, giving an exhaustive collection of the findings of recent investigations.
Export Options
About this article
Cite this article as:
Muzzalupo Rita and Tavano Lorena, Advances on Magnetic Nanocarriers Based on Natural Polymers, Current Pharmaceutical Design 2016; 22 (22) . https://dx.doi.org/10.2174/1381612822666160209152214
DOI https://dx.doi.org/10.2174/1381612822666160209152214 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Activation of Sphingosine Kinase-1 in Cancer: Implications for Therapeutic Targeting
Current Molecular Pharmacology Nanomedicines as Cancer Therapeutics: Current Status
Current Cancer Drug Targets Tyrosine Kinases as New Molecular Targets in Treatment of Inflammatory Disorders and Leukemia
Current Pharmaceutical Design Nanosuspension: A Potential Nanoformulation for Improved Delivery of Poorly Bioavailable Drug
Micro and Nanosystems Recent Developments in Taxane Drug Delivery
Current Drug Delivery The Impact of the Emerging Genomics Data on the Management of Agerelated Phenotypes in the Context of Cellular Senescence
Current Drug Targets Innovative Drug Delivery Systems for the Administration of Natural Compounds
Current Bioactive Compounds Non-histone Methylation of SET7/9 and its Biological Functions
Recent Patents on Anti-Cancer Drug Discovery Enhanced Antisense Oligonucleotide Delivery Using Cationic Liposomes Incorporating Fatty Acid-Modified Polyethylenimine
Current Pharmaceutical Biotechnology Understanding Pre-Structured Motifs (PreSMos) in Intrinsically Unfolded Proteins
Current Protein & Peptide Science Circulating Biomarkers for Tumor Angiogenesis: Where Are We?
Current Medicinal Chemistry Insulin-like Growth Factor: Current Concepts and New Developments in Cancer Therapy
Recent Patents on Anti-Cancer Drug Discovery Clinical Evidence of Herb-Drug Interactions: A Systematic Review by the Natural Standard Research Collaboration
Current Drug Metabolism Paris Saponin VII Induces Apoptosis and Cell Cycle Arrest in Erythroleukemia Cells by a Mitochondrial Membrane Signaling Pathway
Anti-Cancer Agents in Medicinal Chemistry Application of Proteome Analysis to the Assessment of Prognosis and Response Prediction in Clinical Oncology
Current Cancer Drug Targets Application of Biological Study for Met Expression to Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry Retrocyclins: Using Past as Prologue
Current Protein & Peptide Science Pharmacogenomics of Xenobiotic Metabolizing Enzymes in South American Populations
Current Pharmacogenomics Estrogen(s) and Analogs as a Non-Immunogenic Endogenous Ligand in Targeted Drug/DNA Delivery
Current Medicinal Chemistry Biologically Active Selenophenes and Benzo[b]selenophenes
Current Organic Synthesis