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Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Synthesis and Cytotoxicity of Two Active Metabolites of Larotaxel

Author(s): Jianwei Li, Anping Li, Minghua Li, Yufeng Qiao and Hui Zhang

Volume 16, Issue 7, 2016

Page: [875 - 880] Pages: 6

DOI: 10.2174/1871520616666160201151344

Price: $65

Abstract

Two epimeric metabolites of Larotaxel were synthesized in eight steps from 10-DAB III as a commercial material and their structures were characterized using NMR and MS spectral data. The cytotoxicity of two metabolites was performed on breast cancer cell lines MCF-7, MX-1 and MDA-MB-231. It is remarkable that both of these two desired taxanes showed great potent cytotoxic effect.

Keywords: Larotaxel, taxanes, synthesis, MCF-7, cytotoxicity, breast cancer.

Graphical Abstract

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