Abstract
Background: Calreticulin is a Ca2+-binding chaperone in the endoplasmic reticulum (ER) which is crucial to the correct embryological development of the heart in mice. Altered expression levels in the adult were correlated with several cardiac pathologies such as cardiac hypertrophy and dilated cardiomyopathy.
Aim: In this review, we aim to describe the role of calreticulin in the embryological development of the heart in mice and to clarify the relationship between the different cardiac pathologies and altered expression levels of calreticulin in the adult heart.
Conclusion: There is an ER crucial to embryogenesis in cardiomyocytes besides SR. Certain stimuli may induce reactivation of the transcription pattern present during embryogenesis, leading to overexpression of calreticulin in the heart, altering numerous signaling pathways and subsequently inducing pathology. Normalization of these transcriptional disorders holds promise in the treatment of multiple cardiac diseases.
Keywords: Calreticulin, endoplasmic reticulum, fetal lethality, hypertrophy, ischemia-reperfusion, dilated cardiomyopathy, arrhythmia, heart block.
Current Molecular Medicine
Title:Calreticulin in the Heart: From Embryological Development to Cardiac Pathology.
Volume: 16 Issue: 1
Author(s): D. Martinho-Dias, A. Leite-Moreira and P. Castro-Chaves
Affiliation:
Keywords: Calreticulin, endoplasmic reticulum, fetal lethality, hypertrophy, ischemia-reperfusion, dilated cardiomyopathy, arrhythmia, heart block.
Abstract: Background: Calreticulin is a Ca2+-binding chaperone in the endoplasmic reticulum (ER) which is crucial to the correct embryological development of the heart in mice. Altered expression levels in the adult were correlated with several cardiac pathologies such as cardiac hypertrophy and dilated cardiomyopathy.
Aim: In this review, we aim to describe the role of calreticulin in the embryological development of the heart in mice and to clarify the relationship between the different cardiac pathologies and altered expression levels of calreticulin in the adult heart.
Conclusion: There is an ER crucial to embryogenesis in cardiomyocytes besides SR. Certain stimuli may induce reactivation of the transcription pattern present during embryogenesis, leading to overexpression of calreticulin in the heart, altering numerous signaling pathways and subsequently inducing pathology. Normalization of these transcriptional disorders holds promise in the treatment of multiple cardiac diseases.
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Cite this article as:
Martinho-Dias D., Leite-Moreira A. and Castro-Chaves P., Calreticulin in the Heart: From Embryological Development to Cardiac Pathology., Current Molecular Medicine 2016; 16 (1) . https://dx.doi.org/10.2174/1566524016666151222142816
DOI https://dx.doi.org/10.2174/1566524016666151222142816 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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