Abstract
Cardiovascular diseases (CVD) are the main object of morbidity and death in the world. There are different triggers of CVD, but atherosclerosis and/or hypertension are the most usual. CVD risk factors are used as prognosticators of disease process, while the biomarkers that envisage cardiovascular risk have an important biological basis. The integration of CVD risk factors and new biomarkers can improve CVD risk stratification and disease management. The identification of microparticles (MPs) in body fluids has opened new perspectives in diagnosis, prognosis and therapy of CVD pathogenesis. MPs are submicron vesicles released from a diversity of cell types with pleiotropic biological effects on signaling among cells. They are correlated with disease state and play a major role in atherosclerosis associated with inflammation, thrombosis as well as in CVD development and progression. This review reveals many sides of MPs as risk factors, biomarkers, novel forms of intercellular communication, non-invasive potential diagnostic tools and discusses their positive and negative impact on CVD.
Keywords: Biomarkers, cardiovascular disease, diagnostic tools, microparticles.
Current Stem Cell Research & Therapy
Title:Microparticles: From Biogenesis to Biomarkers and Diagnostic Tools in Cardiovascular Disease
Volume: 12 Issue: 2
Author(s): Nicoleta Alexandru, Ana Costa, Alina Constantin, Daniel Cochior and Adriana Georgescu
Affiliation:
Keywords: Biomarkers, cardiovascular disease, diagnostic tools, microparticles.
Abstract: Cardiovascular diseases (CVD) are the main object of morbidity and death in the world. There are different triggers of CVD, but atherosclerosis and/or hypertension are the most usual. CVD risk factors are used as prognosticators of disease process, while the biomarkers that envisage cardiovascular risk have an important biological basis. The integration of CVD risk factors and new biomarkers can improve CVD risk stratification and disease management. The identification of microparticles (MPs) in body fluids has opened new perspectives in diagnosis, prognosis and therapy of CVD pathogenesis. MPs are submicron vesicles released from a diversity of cell types with pleiotropic biological effects on signaling among cells. They are correlated with disease state and play a major role in atherosclerosis associated with inflammation, thrombosis as well as in CVD development and progression. This review reveals many sides of MPs as risk factors, biomarkers, novel forms of intercellular communication, non-invasive potential diagnostic tools and discusses their positive and negative impact on CVD.
Export Options
About this article
Cite this article as:
Alexandru Nicoleta, Costa Ana, Constantin Alina, Cochior Daniel and Georgescu Adriana, Microparticles: From Biogenesis to Biomarkers and Diagnostic Tools in Cardiovascular Disease, Current Stem Cell Research & Therapy 2017; 12 (2) . https://dx.doi.org/10.2174/1574888X11666151203224058
DOI https://dx.doi.org/10.2174/1574888X11666151203224058 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Airway Management in Pediatric Head and Neck Infections
Infectious Disorders - Drug Targets Dietary Factors and Hyperuricaemia
Current Pharmaceutical Design Cardiovascular Disease: A Target for the Pharmacological Effects of Quercetin
Current Topics in Medicinal Chemistry Biology and Therapeutic Applications of Peroxisome Proliferator- Activated Receptors
Current Topics in Medicinal Chemistry Ezetimibe and Vascular Endothelial Function
Current Vascular Pharmacology The Protective Effect of DL0805 Derivatives on Pulmonary Artery Cells and the Underlying Mechanisms Study
Current Vascular Pharmacology Atheroma Burden and Morphology in Women
Current Pharmaceutical Design Hemoglobin Encapsulated Poly(Ethylene Glycol) Surface Conjugated Vesicles Attenuate Vasoactivity of Cell-Free Hemoglobin
Current Drug Discovery Technologies Current and Future Therapeutic Strategies in NAFLD
Current Pharmaceutical Design Preface [Hot topic: Diabetes (Guest Editor: Alex M. DePaoli)]
Current Drug Targets - Immune, Endocrine & Metabolic Disorders A Long Time History of a Mediastinal Fibrosis with Triple Vascular Stenosis
Current Respiratory Medicine Reviews Cholesteryl Ester Transfer Protein rs1532624 Gene Polymorphism is Associated with Reduced Response to Statin Therapy
Current Molecular Pharmacology Effect of Cardiovascular Injury on Catabolism of Adenosine and Adenosine 5-‘Triphosphate in Systemic Blood in a Freely Moving Rat Model In Vivo
Drug Metabolism Letters Patent Selections
Recent Patents on DNA & Gene Sequences Meet Our Editorial Board Member
Current Aging Science Lipid-Lowering Therapies for Atherosclerosis: Statins, Fibrates, Ezetimibe and PCSK9 Monoclonal Antibodies
Current Medicinal Chemistry Differential Effects of Trans and Polyunsaturated Fatty Acids on Ischemia/ Reperfusion Injury and its Associated Cardiovascular Disease States
Current Pharmaceutical Design Presence of Distinct Virtual Backbone Torsion angles in Dipeptide Conformers
Protein & Peptide Letters Infant Breast-Feeding and Suppression of Biomarkers of Future Cardiovascular Disease
Current Nutrition & Food Science Hypoxia and Fetal Heart Development
Current Molecular Medicine