Abstract
NO is a key signaling molecule that has a wide range of biological functions including vasodilation and neurotransmission, and is implicated in several pathological conditions. Therefore, modulation of NO is a desired step in curbing the NO-associated disease processes. Targetting NOS proteins and inhibiting their activity to reduce NO production is a major approach since the inception of NOS inhibitor research. Although a series of NOS inhibitors have been developed, synthesized and practiced in experimental biology, no NOS inhibitor has been approved as yet a drug for therapeutic uses. The present review elaborates the scope of the clinical uses of NOS inhibitors and the inherent limitations of the process that makes the approach less successful so far in clinic.
Keywords: Nitric Oxide (NO), Nitric Oxide Synthase (NOS), Nitric Oxide Synthase inhibitors, NOS oxidase domain, NOS reductase domain.
Current Enzyme Inhibition
Title:Inhibitors of Nitric Oxide Synthase: What's up and What's Next?
Volume: 12 Issue: 1
Author(s): Lakshmikirupa Sundaresan, Suvendu Giri and Suvro Chatterjee
Affiliation:
Keywords: Nitric Oxide (NO), Nitric Oxide Synthase (NOS), Nitric Oxide Synthase inhibitors, NOS oxidase domain, NOS reductase domain.
Abstract: NO is a key signaling molecule that has a wide range of biological functions including vasodilation and neurotransmission, and is implicated in several pathological conditions. Therefore, modulation of NO is a desired step in curbing the NO-associated disease processes. Targetting NOS proteins and inhibiting their activity to reduce NO production is a major approach since the inception of NOS inhibitor research. Although a series of NOS inhibitors have been developed, synthesized and practiced in experimental biology, no NOS inhibitor has been approved as yet a drug for therapeutic uses. The present review elaborates the scope of the clinical uses of NOS inhibitors and the inherent limitations of the process that makes the approach less successful so far in clinic.
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Sundaresan Lakshmikirupa, Giri Suvendu and Chatterjee Suvro, Inhibitors of Nitric Oxide Synthase: What's up and What's Next?, Current Enzyme Inhibition 2016; 12 (1) . https://dx.doi.org/10.2174/1573408012666151126185922
DOI https://dx.doi.org/10.2174/1573408012666151126185922 |
Print ISSN 1573-4080 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6662 |
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