Abstract
Background: The present study has made great progress in multifunctional nanomaterials, which have great potential in cancer diagnosis and therapy.
Methods: In this paper, we proposed a new multifunctional nanocomposite (HGN@RhB-BSA/DOX) which bovine serum albumin (BSA) and doxorubicin (DOX) were modified onto hollow gold nanosphere (HGN) by the electrostatic interaction, and fluorescent dye Rhodamine B (RhB) was combined with bovine serum albumin (BSA) by coupling agent 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC)/N-hydroxysuccinimide sodium salt (Sulfo-NHS).
Results: Based on absorption spectrometer, fluorescence spectrometer, and ZetaSizer analyzer, the nanocomposite had strong surface plasmon resonance (SPR) absorption near 800 nm and revealed the success of RhB, BSA, and DOX were bound onto HGN. The significant rising of temperature was observed when multifunctional fluorescent drug-loaded nanoparticle were irradiated with near-infrared (NIR) light.
Conclusion: We conclude that the nanocomposite presents a promising for photothermal therapy, fluorescence imaging and drug delivery.
Keywords: Fluorescent dye, hollow gold nanosphere, multi-modal imaging, photothermal therapy.
Graphical Abstract
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
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