Abstract
A novel structure of ferrocene derivative 1 was synthesized with cyanuric chloride and ferrocenemethanol as starting materials. The synthesized compound was fully characterized using 1H NMR, 13C NMR, MS and XRD. Subsequently, the in vitro anticancer effect against A549, HCT116 and MCF-7 cell lines was preliminarily evaluated by the MTT method. The result showed that this compound exhibits good cytotoxic effect on A549, HCT116 and MCF-7 cell lines.
Keywords: Ferrocene derivative, synthesis, characterization, NMR, XRD, anticancer activity.
Medicinal Chemistry
Title:Synthesis, Structural Characterization of a Novel Ferrocene Derivative and Preliminarily Anticancer Activity
Volume: 12 Issue: 5
Author(s): Jianping Yong, Xiaoyuan Wu, Jianzhen Liao, Canzhong Lu and Xiaolong Liu
Affiliation:
Keywords: Ferrocene derivative, synthesis, characterization, NMR, XRD, anticancer activity.
Abstract: A novel structure of ferrocene derivative 1 was synthesized with cyanuric chloride and ferrocenemethanol as starting materials. The synthesized compound was fully characterized using 1H NMR, 13C NMR, MS and XRD. Subsequently, the in vitro anticancer effect against A549, HCT116 and MCF-7 cell lines was preliminarily evaluated by the MTT method. The result showed that this compound exhibits good cytotoxic effect on A549, HCT116 and MCF-7 cell lines.
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Cite this article as:
Yong Jianping, Wu Xiaoyuan, Liao Jianzhen, Lu Canzhong and Liu Xiaolong, Synthesis, Structural Characterization of a Novel Ferrocene Derivative and Preliminarily Anticancer Activity, Medicinal Chemistry 2016; 12 (5) . https://dx.doi.org/10.2174/1573406412666151112125345
DOI https://dx.doi.org/10.2174/1573406412666151112125345 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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Carbohydrates are the most essential organic molecules and are involved in the maintenance of various physiological and metabolic processes in living organisms. Carbohydrate-based compounds have come to the attention of researchers because of their significant contributions to biological functions, such as cell development and cell proliferation, connections between several cells, ...read more
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