Abstract
Hybrid imaging devices including PET/CT and SPECT/CT have seen a great success since these scanners found their way into clinical routine – although this success is mainly based on the use in oncological imaging. But also the advent of PET/MRI holds great promise. The combined assessment of molecular imaging and morphology making use of the variety of PET tracers and the high spatial resolution from CT or MRI has the potential of an increased diagnostic accuracy all imaging but especially in cardiovascular questions. We put special emphasis on PET/MR although the experience is still limited. However, as the use of MR imaging in the assessment of myocardial viability as a prime example where assessing myocardial metabolism – even if done so indirectly - is so widespread in clinical reality, this appears to be justified. Thus, in this review, we aim to outline technical characteristics of hybrid imaging systems and highlight their use in cardiovascular diseases and their applications.
Keywords: PET, cardiac imaging, metabolism, perfusion, hybrid imaging, PET/MR, PET/CT, attenuation correction, workflows, dynamic imaging.
Current Pharmaceutical Design
Title:Assessing Myocardial Metabolism with Hybrid PET Imaging: Instrumentation, Concepts, and Workflows
Volume: 22 Issue: 1
Author(s): Stephan G. Nekolla and Christoph Rischpler
Affiliation:
Keywords: PET, cardiac imaging, metabolism, perfusion, hybrid imaging, PET/MR, PET/CT, attenuation correction, workflows, dynamic imaging.
Abstract: Hybrid imaging devices including PET/CT and SPECT/CT have seen a great success since these scanners found their way into clinical routine – although this success is mainly based on the use in oncological imaging. But also the advent of PET/MRI holds great promise. The combined assessment of molecular imaging and morphology making use of the variety of PET tracers and the high spatial resolution from CT or MRI has the potential of an increased diagnostic accuracy all imaging but especially in cardiovascular questions. We put special emphasis on PET/MR although the experience is still limited. However, as the use of MR imaging in the assessment of myocardial viability as a prime example where assessing myocardial metabolism – even if done so indirectly - is so widespread in clinical reality, this appears to be justified. Thus, in this review, we aim to outline technical characteristics of hybrid imaging systems and highlight their use in cardiovascular diseases and their applications.
Export Options
About this article
Cite this article as:
G. Nekolla Stephan and Rischpler Christoph, Assessing Myocardial Metabolism with Hybrid PET Imaging: Instrumentation, Concepts, and Workflows, Current Pharmaceutical Design 2016; 22 (1) . https://dx.doi.org/10.2174/1381612822666151109112519
DOI https://dx.doi.org/10.2174/1381612822666151109112519 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
QT Interval Prolongation: Preclinical and Clinical Testing Arrhythmogenesis in Drugs and Regulatory Implications
Current Drug Safety Recent Advances in Perioperative Anesthetic Management Update in the Perioperative Support of Patients with Septic Shock and the Effect on Outcomes
Current Pharmaceutical Design The Genetics of Small-Vessel Disease
Current Medicinal Chemistry Non-Hormonal Replacement Therapy Regimens: Do they have an Effect on Cardiovascular Risk?
Current Vascular Pharmacology Retraction Note: Phytochemicals from Plants to Combat Cardiovascular Disease
Current Medicinal Chemistry Bedaquiline: A New Hope for Shorter and Better Anti-Tuberculosis Regimens
Recent Patents on Anti-Infective Drug Discovery Novel Approaches Towards Designing of Isoform-Selective Inhibitors Against Class II Histone Deacetylases: The Acute Requirement for Targetted Anticancer Therapy
Current Topics in Medicinal Chemistry Relaxin in Vascular Physiology and Pathophysiology: Possible Implications in Ischemic Brain Disease
Current Neurovascular Research An Update on Peptide Drugs for Voltage-Gated Calcium Channels
Recent Patents on CNS Drug Discovery (Discontinued) Interleukin 2 in Cancer Therapy
Current Medicinal Chemistry Bio-Active Chemical Constituents from the Genus Streptocaulon
Mini-Reviews in Organic Chemistry Clinically Relevant Extracellular-Matrix Scaffolds for Cell Transplantation and Vascular Repair
Current Vascular Pharmacology Brief Daily Episode of Normoxia Inhibits Cardioprotection Conferred by Chronic Continuous Hypoxia. Role of Oxidative Stress and BK<sub>Ca</sub> Channels
Current Pharmaceutical Design Adenosine Receptor Ligands in Clinical Trials
Current Topics in Medicinal Chemistry Design, Synthesis, Pharmacological Evaluation and Descriptor Based Similarities Study of N,N-diphenyl-2-[4-(substituted phenyl)piperazin-1- yl]acetamides as Potential Antipsychotics
Medicinal Chemistry Neurologic and Cardiovascular Complications in Pediatric Life Threatening Imipramine Poisoning
Current Drug Safety Food Allergy
Current Pharmaceutical Design The GH/IGF-1 Axis and Heart Failure
Current Cardiology Reviews Staged Starnes Operation Preserving Patent Ductus Arteriosus for Neonates with Ebsteins Anomaly and Pulmonary Atresia
Current Cardiology Reviews A Guide to Treatment of Sarcoidosis
Current Drug Therapy