Abstract
The structure-based drug design has been an extremely useful technique used for searching and developing of new therapeutic agents in various biological systems. In the case of AD, this approach has been difficult to implement. Among other several causes, the main problem might be the lack of a specific stable and reliable molecular target. In this paper the results obtained using a pentameric amyloid beta (Aβ) model as a molecular target are discussed. Our MD simulations have shown that this system is relatively structured and stable, displaying a lightly conformational flexibility during 2.0 μs of simulation time. This study allowed us to distinguish characteristic structural features in specific regions of the pentamer which should be taken into account when choosing this model as a molecular target. This represents a clear advantage compared to the monomer or dimer models which are highly flexible structures with large numbers of possible conformers. Using this pentameric model we performed two types of studies usually carried out on a molecular target: a virtual screening and the design on structural basis of new mimetic peptides with antiaggregant properties. Our results indicate that this pentameric model might be a good molecular target for these particular studies of molecular modeling. Details about the predictive power of our virtual screening as well as about the molecular interactions that stabilize the mimetic peptide-pentamer Aβ complexes are discussed in this paper
Keywords: Pentameric model, molecular target, MD simulations, antiaggregant compounds, virtual screening, mimetic peptides.
Current Protein & Peptide Science
Title:Pentameric models as alternative molecular targets for the design of new antiaggregant agents
Volume: 17 Issue: 2
Author(s): Exequiel E. Barrera Guisasola, Lucas J. Gutierrez, Sebastián A. Andujar, Emilio Angelina, Ana M. Rodríguez and Ricardo D. Enriz
Affiliation:
Keywords: Pentameric model, molecular target, MD simulations, antiaggregant compounds, virtual screening, mimetic peptides.
Abstract: The structure-based drug design has been an extremely useful technique used for searching and developing of new therapeutic agents in various biological systems. In the case of AD, this approach has been difficult to implement. Among other several causes, the main problem might be the lack of a specific stable and reliable molecular target. In this paper the results obtained using a pentameric amyloid beta (Aβ) model as a molecular target are discussed. Our MD simulations have shown that this system is relatively structured and stable, displaying a lightly conformational flexibility during 2.0 μs of simulation time. This study allowed us to distinguish characteristic structural features in specific regions of the pentamer which should be taken into account when choosing this model as a molecular target. This represents a clear advantage compared to the monomer or dimer models which are highly flexible structures with large numbers of possible conformers. Using this pentameric model we performed two types of studies usually carried out on a molecular target: a virtual screening and the design on structural basis of new mimetic peptides with antiaggregant properties. Our results indicate that this pentameric model might be a good molecular target for these particular studies of molecular modeling. Details about the predictive power of our virtual screening as well as about the molecular interactions that stabilize the mimetic peptide-pentamer Aβ complexes are discussed in this paper
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Cite this article as:
Barrera Guisasola E. Exequiel, Gutierrez J. Lucas, Andujar A. Sebastián, Angelina Emilio, Rodríguez M. Ana and Enriz D. Ricardo, Pentameric models as alternative molecular targets for the design of new antiaggregant agents, Current Protein & Peptide Science 2016; 17 (2) . https://dx.doi.org/10.2174/1389203716666151102104926
DOI https://dx.doi.org/10.2174/1389203716666151102104926 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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