Abstract
Alzheimer's disease (AD) is a neurodegenerative disorder that gradually induces cognitive deficit. Working memory deficits have been previously reported in AD and Amyloid-β peptide (Aβ) is regarded as a causative factor for the impairments. Accumulating evidence has identified that neuronal ensemble activity as well as functional connectivity among neurons encode and process information in normal brain. How Aβ contributes to the abnormal neuronal ensemble activity and corresponding functional connectivity which, in turn, leads to the cognitive deficits? To address the issue, we simultaneously recorded neuronal activity from medial prefrontal cortex of rats (control and Aβ injected group) when the rats performed a Y-maze working memory task, to investigate the properties of neuronal ensemble activity and functional connectivity. In the control group, a group of neurons were collectively activated and the connectivity among the neurons strengthened during the working memory task. However, in the Aβ group, the neuronal activity and connectivity never experience significant change. Our results indicate that the dysfunction of neuronal activity and connectivity may provide insight for the Aβ-induced working memory deficits.
Keywords: Alzheimer's disease (AD), amyloid-β peptide (Aβ), functional connectivity, neuronal ensemble activity, rat, working memory.
Current Alzheimer Research
Title:Aberrant Neuronal Activity and Dysfunctional Connectivity in Aβ1–42- mediated Memory Deficits in Rats
Volume: 12 Issue: 10
Author(s): Jing Wei, Hu Yi, Dan Zhang, Wenwen Bai and Xin Tian
Affiliation:
Keywords: Alzheimer's disease (AD), amyloid-β peptide (Aβ), functional connectivity, neuronal ensemble activity, rat, working memory.
Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder that gradually induces cognitive deficit. Working memory deficits have been previously reported in AD and Amyloid-β peptide (Aβ) is regarded as a causative factor for the impairments. Accumulating evidence has identified that neuronal ensemble activity as well as functional connectivity among neurons encode and process information in normal brain. How Aβ contributes to the abnormal neuronal ensemble activity and corresponding functional connectivity which, in turn, leads to the cognitive deficits? To address the issue, we simultaneously recorded neuronal activity from medial prefrontal cortex of rats (control and Aβ injected group) when the rats performed a Y-maze working memory task, to investigate the properties of neuronal ensemble activity and functional connectivity. In the control group, a group of neurons were collectively activated and the connectivity among the neurons strengthened during the working memory task. However, in the Aβ group, the neuronal activity and connectivity never experience significant change. Our results indicate that the dysfunction of neuronal activity and connectivity may provide insight for the Aβ-induced working memory deficits.
Export Options
About this article
Cite this article as:
Wei Jing, Yi Hu, Zhang Dan, Bai Wenwen and Tian Xin, Aberrant Neuronal Activity and Dysfunctional Connectivity in Aβ1–42- mediated Memory Deficits in Rats, Current Alzheimer Research 2015; 12 (10) . https://dx.doi.org/10.2174/1567205012666151027141324
DOI https://dx.doi.org/10.2174/1567205012666151027141324 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
Call for Papers in Thematic Issues
New Advances in the Prevention, Diagnosis, Treatment, and Rehabilitation of Alzheimer's Disease
Aims and Scope: Introduction: Alzheimer's disease (AD) poses a significant global health challenge, with an increasing prevalence that demands concerted efforts to advance our understanding and strategies for prevention, diagnosis, treatment, and rehabilitation. This thematic issue aims to bring together cutting-edge research and innovative approaches from multidisciplinary perspectives to address ...read more
Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
Deep Learning for Advancing Alzheimer's Disease Research
Alzheimer's disease (AD) poses a significant global health challenge, with an increasing number of individuals affected yearly. Deep learning, a subfield of artificial intelligence, has shown immense potential in various domains, including healthcare. This thematic issue of Current Alzheimer Research explores the application of deep learning techniques in advancing our ...read more
Diagnostic and therapeutic biomarkers of dementia
Dementia affects 18 million people worldwide. Dementia is a syndrome of symptoms caused by brain disease, usually chronic or progressive, clinically characterized by multiple impairments of higher cortical functions such as memory, thinking, orientation, and learning. In addition, in the course of dementia, cognitive deficits are observed, which often hinder ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Hydrophobic Plant Antioxidants. Preparation of Nanoparticles and their Application for Prevention of Neurodegenerative Diseases. Review and Experimental Data
Current Topics in Medicinal Chemistry The Role for Oxidative Stress in Aberrant DNA Methylation in Alzheimer’s Disease
Current Alzheimer Research P2X7 Receptors: Channels, Pores and More
CNS & Neurological Disorders - Drug Targets Oxidative Stress in Traumatic Brain Injury
Current Medicinal Chemistry Bioenergetics and Mitochondrial Dysfunction in Aging: Recent Insights for a Therapeutical Approach
Current Pharmaceutical Design Harnessing the Capacity of Cell-Penetrating Peptides for Drug Delivery to the Central Nervous System
Current Pharmaceutical Biotechnology Is β-catenin neutralization cross-involved in the mechanisms mediated by natalizumab action?
Current Molecular Medicine Editorial (Thematic Issue: Immunotherapy in Central Nervous System)
Current Pharmaceutical Biotechnology Uridine Function in the Central Nervous System
Current Topics in Medicinal Chemistry Antioxidant Effects of Natural Bioactive Compounds
Current Pharmaceutical Design CNS Drug Delivery Systems: Novel Approaches
Recent Patents on Drug Delivery & Formulation Mitochondrial Proteases as Emerging Pharmacological Targets
Current Pharmaceutical Design Post-Translational Modifications in Prion Proteins
Current Protein & Peptide Science Editorial [Hot topic: Antiretroviral, Anti-Inflammatory and Dopaminergic Substances in the Treatment of HIV-Infection (Guest Editor: Gabriele Arendt)]
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Applying Knowledge of Enzyme Biochemistry to the Prediction of Functional Sites for Aiding Drug Discovery
Current Topics in Medicinal Chemistry The Panomics Approach in Neurodegenerative Disorders
Current Medicinal Chemistry Optimization and Assay of Antioxidant Potential of Two Penicillium spp. by Different Procedures
Current Biotechnology Mitochondria as Possible Pharmaceutical Targets for the Effects of Vitamin E and its Homologues in Oxidative Stress-Related Diseases
Current Pharmaceutical Design Meet Our Editorial Board Member
Current Alzheimer Research Will it Ever Become Possible to Prevent Dopaminergic Neuronal Degeneration?
CNS & Neurological Disorders - Drug Targets