Abstract
During past two decades, plant-derived bioactive compounds have been reported as novel therapeutic agents for prevention and/or mitigation of different human diseases such as cancer, inflammation, cardiovascular and neurodegenerative diseases. Hesperidin is known as one of the most common and bioactive constituents of Citrus (C) species which possesses multiple health-promotion effects. A plethora of scientific literature reported that hesperidin possesses in-vitro and in-vivo anticancer activities. In addition, there are numerous scientific evidences regarding the molecular mechanisms of anticancer activities of hesperidin and its aglycone, hesperetin. However, in this case, the number of comprehensive reviews on molecular mechanisms underlying the anticancer effects of hesperidin is sparse. Therefore, in this work we present a critical review of the available literature regarding the molecular mechanisms of the anticancer effects of hesperidin and its aglycone, hesperetin.
Keywords: Aglycone, anticancer, citrus, flavonoid, hesperetin, hesperidin.
Current Medicinal Chemistry
Title:The Role of Hesperidin in Cell Signal Transduction Pathway for the Prevention or Treatment of Cancer
Volume: 22 Issue: 30
Author(s): A. Ahmadi, A. Shadboorestan, S.F. Nabavi, W.N. Setzer and S.M. Nabavi
Affiliation:
Keywords: Aglycone, anticancer, citrus, flavonoid, hesperetin, hesperidin.
Abstract: During past two decades, plant-derived bioactive compounds have been reported as novel therapeutic agents for prevention and/or mitigation of different human diseases such as cancer, inflammation, cardiovascular and neurodegenerative diseases. Hesperidin is known as one of the most common and bioactive constituents of Citrus (C) species which possesses multiple health-promotion effects. A plethora of scientific literature reported that hesperidin possesses in-vitro and in-vivo anticancer activities. In addition, there are numerous scientific evidences regarding the molecular mechanisms of anticancer activities of hesperidin and its aglycone, hesperetin. However, in this case, the number of comprehensive reviews on molecular mechanisms underlying the anticancer effects of hesperidin is sparse. Therefore, in this work we present a critical review of the available literature regarding the molecular mechanisms of the anticancer effects of hesperidin and its aglycone, hesperetin.
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Ahmadi A., Shadboorestan A., Nabavi S.F., Setzer W.N. and Nabavi S.M., The Role of Hesperidin in Cell Signal Transduction Pathway for the Prevention or Treatment of Cancer, Current Medicinal Chemistry 2015; 22 (30) . https://dx.doi.org/10.2174/092986732230151019103810
DOI https://dx.doi.org/10.2174/092986732230151019103810 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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