Abstract
It has been over half a century since propranolol, the first beta-blocker, was developed for medical treatment. Since that time a large number of compounds from this group have been synthesised and many are now in clinical use. The structure, function, pharmacokinetics, and mechanism of beta-blockers have been established. The possibilities for their use in treating different conditions continue to evolve. Since the discovery of later generation beta-blockers, such as carvedilol and nebivolol, the search for new compounds continues, and may include known substances with betablocking properties which could extend their therapeutic potential.
Keywords: Activity, application, aryloxyaminopropanol derivatives, beta-blockers, structure.
Mini-Reviews in Medicinal Chemistry
Title:Beta-Blockers: Current State of Knowledge and Perspectives
Volume: 16 Issue: 1
Author(s): Magdalena Ogrodowczyk, Katarzyna Dettlaff and Anna Jelinska
Affiliation:
Keywords: Activity, application, aryloxyaminopropanol derivatives, beta-blockers, structure.
Abstract: It has been over half a century since propranolol, the first beta-blocker, was developed for medical treatment. Since that time a large number of compounds from this group have been synthesised and many are now in clinical use. The structure, function, pharmacokinetics, and mechanism of beta-blockers have been established. The possibilities for their use in treating different conditions continue to evolve. Since the discovery of later generation beta-blockers, such as carvedilol and nebivolol, the search for new compounds continues, and may include known substances with betablocking properties which could extend their therapeutic potential.
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Cite this article as:
Ogrodowczyk Magdalena, Dettlaff Katarzyna and Jelinska Anna, Beta-Blockers: Current State of Knowledge and Perspectives, Mini-Reviews in Medicinal Chemistry 2016; 16 (1) . https://dx.doi.org/10.2174/1389557515666151016125948
DOI https://dx.doi.org/10.2174/1389557515666151016125948 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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