Abstract
Background: The widespread application of fluorine in drug design benefits from distinctive properties. Incorporation of fluorine can positively modulate certain pharmacokinetics properties, including lipophilicity, eletrophilicity, metabolic stability, chemical stability, et al., which were of interest to medicinal chemists. Herein, fluorinated compounds, which have been designed and evaluated for anticancer, antimicrobial, anti-inflammatory and antivirus activity, et al. during the last 6 years (2010-2015) are summarized.
Conclusion: The emphasis is to highlight the importance of fluorinated compounds and the changes in the properties of compounds when introducing fluorine atom.Keywords: Application of fluorine, anticancer, antimicrobial, anti-inflammatory, antivirus activity, drug design, importance of fluorinated compounds.
Mini-Reviews in Medicinal Chemistry
Title:Application of Fluorine in Drug Design During 2010-2015 Years: A Mini-Review
Volume: 17 Issue: 8
Author(s): Bao-Cheng Wang, Li-Jun Wang, Bo Jiang, Shuai-Yu Wang, Ning Wu, Xiang-Qian Li and Da-Yong Shi*
Affiliation:
- Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071,China
Keywords: Application of fluorine, anticancer, antimicrobial, anti-inflammatory, antivirus activity, drug design, importance of fluorinated compounds.
Abstract: Background: The widespread application of fluorine in drug design benefits from distinctive properties. Incorporation of fluorine can positively modulate certain pharmacokinetics properties, including lipophilicity, eletrophilicity, metabolic stability, chemical stability, et al., which were of interest to medicinal chemists. Herein, fluorinated compounds, which have been designed and evaluated for anticancer, antimicrobial, anti-inflammatory and antivirus activity, et al. during the last 6 years (2010-2015) are summarized.
Conclusion: The emphasis is to highlight the importance of fluorinated compounds and the changes in the properties of compounds when introducing fluorine atom.Export Options
About this article
Cite this article as:
Wang Bao-Cheng, Wang Li-Jun, Jiang Bo, Wang Shuai-Yu, Wu Ning, Li Xiang-Qian and Shi Da-Yong*, Application of Fluorine in Drug Design During 2010-2015 Years: A Mini-Review, Mini-Reviews in Medicinal Chemistry 2017; 17 (8) . https://dx.doi.org/10.2174/1389557515666151016124957
DOI https://dx.doi.org/10.2174/1389557515666151016124957 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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