One of the most complex systems in the human body is the nervous
system, which is divided into the central and peripheral nervous systems.
The regeneration of the CNS is a complex and challenging biological
phenomenon hindered by the low regenerative capacity of neurons and the
prohibition factors in response to nerve injuries. To date, no effective approach
can achieve complete recovery and fully restore the functions of the
nervous system once it has been damaged. Developments in neuroscience
have identified properties of the local environment with a critical role in
nerve regeneration. Advances in biomaterials and biomedical engineering
have explored new approaches of constructing permissive environments for
nerve regeneration, thereby enabling optimism with regard to nerve-injury treatment.
This article reviews recent progress in nanoengineered environments for aiding nerveinjury
repair and regeneration, including nanofibrous scaffolds, functional molecules,
and stem cells.
Keywords: Electrical stimulation, functional molecules, nanoscaffolds, nerve-tissue engineering, stem cells.
Rights & PermissionsPrintExport