Abstract
Diabetes is reaching epidemic proportions worldwide. Many dietary compounds have been found to exert health beneficial effects against different pathologies including diabetes. Most bioactive compounds have been identified in fruits and vegetables and their mechanisms of action explored both in vitro and in vivo. In particular, great interest has been given to polyphenols and especially to a specific subset of molecules, i.e. anthocyanins. Several lines of evidence suggest that anthocyanins have positive effects on human health by inducing a number of biological activities. This review will give an overview on the influence of dietary anthocyanins on preventing and managing type 2 diabetes. In particular, in vitro and in vivo studies will be presented. The article also reviews the potential clinical impact of the antidiabetic activity of anthocyanins and outlines the major challenges of using anthocyanins for diabetes treatment.
Keywords: Anthocyanins, anthocyanidins, antioxidant activity, cyanidin, diabetes, enzymatic mechanisms, non-enzymatic mechanisms.
Current Drug Targets
Title:Possible Effects of Dietary Anthocyanins on Diabetes and Insulin Resistance
Volume: 18 Issue: 6
Author(s): Eleonora Turrini, Lorenzo Ferruzzi and Carmela Fimognari*
Affiliation:
- Department for Life Quality Studies, Alma Mater Studiorum-University of Bologna, Corso d`Augusto, 237 47921 Rimini,Italy
Keywords: Anthocyanins, anthocyanidins, antioxidant activity, cyanidin, diabetes, enzymatic mechanisms, non-enzymatic mechanisms.
Abstract: Diabetes is reaching epidemic proportions worldwide. Many dietary compounds have been found to exert health beneficial effects against different pathologies including diabetes. Most bioactive compounds have been identified in fruits and vegetables and their mechanisms of action explored both in vitro and in vivo. In particular, great interest has been given to polyphenols and especially to a specific subset of molecules, i.e. anthocyanins. Several lines of evidence suggest that anthocyanins have positive effects on human health by inducing a number of biological activities. This review will give an overview on the influence of dietary anthocyanins on preventing and managing type 2 diabetes. In particular, in vitro and in vivo studies will be presented. The article also reviews the potential clinical impact of the antidiabetic activity of anthocyanins and outlines the major challenges of using anthocyanins for diabetes treatment.
Export Options
About this article
Cite this article as:
Turrini Eleonora, Ferruzzi Lorenzo and Fimognari Carmela*, Possible Effects of Dietary Anthocyanins on Diabetes and Insulin Resistance, Current Drug Targets 2017; 18 (6) . https://dx.doi.org/10.2174/1389450116666151001105230
DOI https://dx.doi.org/10.2174/1389450116666151001105230 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
From Test Tube to Clinical Trial; Promising Herbs with NF-κB and COX- 2 Activity
Current Immunology Reviews (Discontinued) Corticosteroids in Sepsis: Pathophysiological Rationale and the Selection of Patients
Endocrine, Metabolic & Immune Disorders - Drug Targets Sunlight Vitamin D and Skin Cancer
Anti-Cancer Agents in Medicinal Chemistry A Critical View of Molecularly Target Therapy for Digestive Endocrine Tumours
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Kinins as Therapeutic Agents in Cardiovascular and Renal Diseases
Current Pharmaceutical Design TRAIL as Biomarker and Potential Therapeutic Tool for Cardiovascular Diseases
Current Drug Targets Oxidative Stress Correlates (OSC) in Diabetes Mellitus Patients
Current Diabetes Reviews Polyphenols: Skin Photoprotection and Inhibition of Photocarcinogenesis
Mini-Reviews in Medicinal Chemistry Large Granular Lymphocyte (LGL) Leukemia: Pathobiology, Diagnosis and Treatment
Current Cancer Therapy Reviews The Novel Antipsychotic Drug Cariprazine and Cognition Enhancing Drugs: Indications for their Use as the Add-on Therapy in Schizophrenia
Current Pharmaceutical Design Current Perspectives for Diabetes and Allostatic Load: The Role of Nutrition
Current Nutrition & Food Science The Histamine H3 Receptor as a Therapeutic Drug Target for Metabolic Disorders: Status, Challenges and Opportunities
Current Topics in Medicinal Chemistry Involvement of IL-1R/TLR Signalling in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis
Current Molecular Medicine Clinical and <i>In Silico</i> Outcomes of the Expression of miR-130a-5p and miR-615-3p in Tumor Compared with Non-Tumor Adjacent Tissues of Patients with BC
Anti-Cancer Agents in Medicinal Chemistry Nicotine Replacement Therapy During Pregnancy and Lactation Induce Structural and Functional Changes in the Lungs of the Progeny
Current Women`s Health Reviews Severe Influenza: Clinical Features and Treatment Options
Current Respiratory Medicine Reviews Cutting through the Complexities of mTOR for the Treatment of Stroke
Current Neurovascular Research Neuropeptides in Psychiatric Diseases: An Overview with a Particular Focus on Depression and Anxiety Disorders
CNS & Neurological Disorders - Drug Targets Beyond RAS: The Role of Epidermal Growth Factor Receptor (EGFR) and its Network in the Prediction of Clinical Outcome During Anti-EGFR Treatment in Colorectal Cancer Patients
Current Drug Targets Role of Innate Immunity in Triggering and Tuning of Autoimmune Diabetes
Current Molecular Medicine