Abstract
Exhaled breath condensate (EBC) pH is a commonly studied biomarker which represents the acidity of the whole airway tract, including the lower and upper airways as well as oral cavity. Because neat, unprocessed EBC pH can be affected by environmental and end-tidal carbon dioxide, two further reproducible techniques have been developed to measure condensate acidity with several methodological, pathophysiological and environmental factors which may influence EBC pH. Airway acidification may contribute to various pathological features of asthma, therefore EBC pH may be a non-invasive, but unspecific clinical biomarker of this disorder. This review summarises the current knowledge on EBC pH in asthma focusing on methodological aspects and possible clinical applications.
Current Topics in Medicinal Chemistry
Title:Methodological Issues and Possible Clinical Implications for Exhaled Breath Condensate pH in Asthma
Volume: 16 Issue: 14
Author(s): Andras Bikov and Ildiko Horvath
Affiliation:
Abstract: Exhaled breath condensate (EBC) pH is a commonly studied biomarker which represents the acidity of the whole airway tract, including the lower and upper airways as well as oral cavity. Because neat, unprocessed EBC pH can be affected by environmental and end-tidal carbon dioxide, two further reproducible techniques have been developed to measure condensate acidity with several methodological, pathophysiological and environmental factors which may influence EBC pH. Airway acidification may contribute to various pathological features of asthma, therefore EBC pH may be a non-invasive, but unspecific clinical biomarker of this disorder. This review summarises the current knowledge on EBC pH in asthma focusing on methodological aspects and possible clinical applications.
Export Options
About this article
Cite this article as:
Bikov Andras and Horvath Ildiko, Methodological Issues and Possible Clinical Implications for Exhaled Breath Condensate pH in Asthma, Current Topics in Medicinal Chemistry 2016; 16 (14) . https://dx.doi.org/10.2174/1568026616666150930120421
DOI https://dx.doi.org/10.2174/1568026616666150930120421 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Gene Vectors for Cytokine Expression In Vivo
Current Pharmaceutical Design Reflections on MicroRNAs in Chronic Pulmonary Disease: Looking into the miR-ror and Crystal Ball
Inflammation & Allergy - Drug Targets (Discontinued) Advances in the Development of Class I Phosphoinositide 3-Kinase (PI3K) Inhibitors
Current Topics in Medicinal Chemistry Short, but Highly Concentrated, Direct Inhalations of Essential Oil Molecules Improve Poor Sleep Quality: A Natural History Controlled, Withingroup, Self-administration Field Pilot Study
Current Psychopharmacology STABIL-study: The Course of Therapy, Safety and Pharmacokinetic Parameters of Conversion of Prograf® to Tacrolimus HEXAL®/Crilomus® in Renal Transplant Recipients – an Observational Study in Germany
Current Reviews in Clinical and Experimental Pharmacology Mechanisms of Neutrophil-mediated Disease: Innovative Therapeutic Interventions
Current Pharmaceutical Design Sulfation of Drug Compounds by the Zebrafish Cytosolic Sulfotransferases (SULTs)
Drug Metabolism Letters Vascular Remodelling and Angiogenesis in Asthma: Morphological Aspects and Pharmacological Modulation
Inflammation & Allergy - Drug Targets (Discontinued) Probiotic Research in Australia, New Zealand and the Asia-Pacific Region
Current Pharmaceutical Design Targeting the L-Arginine-Nitric Oxide Pathway for Cancer Treatment
Current Pharmaceutical Design The Glucocorticoid Receptor: Molecular Mechanism and New Therapeutic Opportunities
Current Drug Targets - Inflammation & Allergy Correlating Low-Similarity Peptide Sequences and Allergenic Epitopes
Current Pharmaceutical Design Identification of Degradation Products by Adopting GC or HPLC/MS Techniques
Current Analytical Chemistry The Impact of 5-Substituted Uracil Derivatives on Immortalized Embryo Lung Cells
Letters in Drug Design & Discovery Biological Activity of Some Volatile Diterpenoids
Current Bioactive Compounds Therapeutic Relevance of Targeting Nuclear Factor kappaB with Transcription Factor Decoy Molecules
Drug Design Reviews - Online (Discontinued) Dietary Approaches and Supplements in the Prevention of Cognitive Decline and Alzheimer's Disease
Current Pharmaceutical Design Editorial [Hot Topic:Metalloproteinases Revisited (Guest Editor: Marcia L. Moss)]
Current Pharmaceutical Biotechnology Nanosponges Encapsulated Phytochemicals for Targeting Cancer: A Review
Current Drug Targets Nanoparticle-Based Diagnosis and Therapy
Current Drug Targets