Total Synthesis of ME1036 Starting from Readily Available Inexpensive Materials

Title:Total Synthesis of ME1036 Starting from Readily Available Inexpensive Materials

Volume: 12 Issue: 10

Author(s): Zhi-Jian Han, Yang-Bing Li, Lu-Xi Yang, Ai-lin Song, Hao Chen and Yu-Min Li

Affiliation:

Keywords: Carbapenem, C-C coupling, diazo compound, glycine amide, ME1036, total synthesis.

Abstract: This work demonstrates the effective total synthesis of a new broad-spectrum parenteral carbapenem starting from the readily available and inexpensive N-Cbz-protected glycine amide in high yield with easy work-up under mild reaction conditions.

Cite this article as:

Han Zhi-Jian, Li Yang-Bing, Yang Lu-Xi, Song Ai-lin, Chen Hao and Li Yu-Min, Total Synthesis of ME1036 Starting from Readily Available Inexpensive Materials, Letters in Organic Chemistry 2015; 12 (10) . https://dx.doi.org/10.2174/1570178612666150924001523