Abstract
Antimicrobial peptides have recently garnered significant attention as an emerging source of potential antibiotics, due to the swift emergence of multidrug-resistant bacteria and a dwindling antibiotic pipeline. The vast majority of antimicrobial peptides are long, comprised of more than 10 amino acids, resulting in significant production costs for their synthesis while simultaneously displaying metabolic instability and relatively poor pharmacological profiles. To counter these problems, efforts have been shifted to shorter molecules and the development of new peptidomimetic approaches. In this paper, we review promising short, naturally-isolated or synthetic, antimicrobial peptides, along with their mimics, and discuss their merits as potential antibacterial agents.
Keywords: Antibacterial peptidomimetics, Antibiotics, Antimicrobial peptides, Bacterial resistance, Cationic amphiphiles, Host-defense peptides
Current Topics in Medicinal Chemistry
Title:Short Antimicrobial Peptides and Peptide Scaffolds as Promising Antibacterial Agents
Volume: 16 Issue: 11
Author(s): Ronald Domalaon, George G. Zhanel and Frank Schweizer
Affiliation:
Keywords: Antibacterial peptidomimetics, Antibiotics, Antimicrobial peptides, Bacterial resistance, Cationic amphiphiles, Host-defense peptides
Abstract: Antimicrobial peptides have recently garnered significant attention as an emerging source of potential antibiotics, due to the swift emergence of multidrug-resistant bacteria and a dwindling antibiotic pipeline. The vast majority of antimicrobial peptides are long, comprised of more than 10 amino acids, resulting in significant production costs for their synthesis while simultaneously displaying metabolic instability and relatively poor pharmacological profiles. To counter these problems, efforts have been shifted to shorter molecules and the development of new peptidomimetic approaches. In this paper, we review promising short, naturally-isolated or synthetic, antimicrobial peptides, along with their mimics, and discuss their merits as potential antibacterial agents.
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Cite this article as:
Domalaon Ronald, Zhanel G. George and Schweizer Frank, Short Antimicrobial Peptides and Peptide Scaffolds as Promising Antibacterial Agents, Current Topics in Medicinal Chemistry 2016; 16 (11) . https://dx.doi.org/10.2174/1568026615666150915112459
DOI https://dx.doi.org/10.2174/1568026615666150915112459 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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