An Efficient Three-Component Reaction of Sodium Azide, Haloalkane and Alkyne for the Synthesis of 1, 2, 3-Triazoles Catalyzed by the Bifunctional Ionic Liquid Catalyst Choline Chloride-CuCl in Water

Title:An Efficient Three-Component Reaction of Sodium Azide, Haloalkane and Alkyne for the Synthesis of 1, 2, 3-Triazoles Catalyzed by the Bifunctional Ionic Liquid Catalyst Choline Chloride-CuCl in Water

Volume: 13 Issue: 3

Author(s): Xuan-Gan Liu, Xian-Liang Zhao, Yan Zhang and Jian-Rong Gao

Affiliation:

Keywords: Aqueous media, choline chloride, CuCl, cycloaddition, ionic liquid catalyst, three-component.

Abstract: 1, 2, 3-Triazoles were synthesized using a one-pot procedure via a threecomponent reaction between an organic halide, sodium azide and alkyne in the presence of an ionic liquid choline chloride-CuCl catalyst. The catalyst can increase the rate of the nucleophilic substitution reaction and showed a high catalytic activity for the [3+2] Huisgen cycloaddition in water. This method is applicable for a wide range of alkynes including aromatic and heterocyclic substrates.

Cite this article as:

Liu Xuan-Gan, Zhao Xian-Liang, Zhang Yan and Gao Jian-Rong, An Efficient Three-Component Reaction of Sodium Azide, Haloalkane and Alkyne for the Synthesis of 1, 2, 3-Triazoles Catalyzed by the Bifunctional Ionic Liquid Catalyst Choline Chloride-CuCl in Water, Letters in Organic Chemistry 2016; 13 (3) . https://dx.doi.org/10.2174/1570178612666150908213423