Abstract
The aim of this review paper is to summarize some marine natural sources (bacteria and fungi) known for their anti-inflammatory effects. We have collected data from MDPI, current contents, scientific research articles and journal publications. This review will give brief idea about the chemistry of novel marine compounds, mechanism of action, metabolites, biological sources of the compounds, synthesis of these marine natural products, as well as use of them in drug discovery and development. Different marine bacteria and fungi live in symbiosis with corals or sponges. Many actives have been isolated from these organisms. The quantity of actives obtained varies in different geographical and environmental conditions. These actives elucidate different mechanisms of action due to presence of different pharmacophore features in novel chemical templates. Efforts have been made to synthesize some structural analogs of isolated active anti-inflammatory compounds and SAR studies conducted. This review gives options for synthesis of new anti-inflammatory compounds thus expanding the chemical space in this category.
Keywords: Actinobacteria, anti-inflammatory, lactones, marine microbes, sesquiterpenes.
The Natural Products Journal
Title:Novel Anti-inflammatory Drugs from Marine Microbes
Volume: 5 Issue: 3
Author(s): Sarvesh S. Rangnekar and Tabassum Khan
Affiliation:
Keywords: Actinobacteria, anti-inflammatory, lactones, marine microbes, sesquiterpenes.
Abstract: The aim of this review paper is to summarize some marine natural sources (bacteria and fungi) known for their anti-inflammatory effects. We have collected data from MDPI, current contents, scientific research articles and journal publications. This review will give brief idea about the chemistry of novel marine compounds, mechanism of action, metabolites, biological sources of the compounds, synthesis of these marine natural products, as well as use of them in drug discovery and development. Different marine bacteria and fungi live in symbiosis with corals or sponges. Many actives have been isolated from these organisms. The quantity of actives obtained varies in different geographical and environmental conditions. These actives elucidate different mechanisms of action due to presence of different pharmacophore features in novel chemical templates. Efforts have been made to synthesize some structural analogs of isolated active anti-inflammatory compounds and SAR studies conducted. This review gives options for synthesis of new anti-inflammatory compounds thus expanding the chemical space in this category.
Export Options
About this article
Cite this article as:
S. Rangnekar Sarvesh and Khan Tabassum, Novel Anti-inflammatory Drugs from Marine Microbes, The Natural Products Journal 2015; 5 (3) . https://dx.doi.org/10.2174/2210315505666150827212323
DOI https://dx.doi.org/10.2174/2210315505666150827212323 |
Print ISSN 2210-3155 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-3163 |
Call for Papers in Thematic Issues
Ayurvedic medicinal therapeutic approaches for inflammatory and neurodegenerative disorders
Usually, in our elderly population, neurodegenerative disorders occur due to neuron death. Alzheimer?s disease (AD) is an irreversible and progressive neurodegenerative disease. Dementia is the leading cause of AD, which affects about 30 million people worldwide. According to the World Alzheimer report 2018, a new case of dementia develops every ...read more
Recent Advances in Biotransformation of Bioactive Terpenoids using Aspergillus niger
Biotransformation is the reaction catalyzed by biological catalysts of either isolated enzymes or whole cell cultures of microorganisms. This process has been extensively applied in the conversion of bioactive terpenoids with high regio- and stereospecifity. This process has been also applied in the lead discovery and development. Aspergillus niger has ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Experimental Fracture Protocols in Assessments of Potential Agents for Osteoporotic Fracture Healing Using Rodent Models
Current Drug Targets Electrospinning for Bone Tissue Engineering
Recent Patents on Nanotechnology Diabetic Vascular Complications: Pathophysiology, Biochemical Basis and Potential Therapeutic Strategy
Current Pharmaceutical Design Benzo[d]imidazol-5-yl)-5-(substituted)-1,3,4-Oxadiazoles: Synthesis, Anticancer, Antimicrobial and In Silico Studies
Letters in Drug Design & Discovery Granulomatous Lung Disease. Disease for Pulmomologists: Diagnosis and Treatment
Current Respiratory Medicine Reviews Lanthanum Carbonate - A New Phosphate Binding Drug in Advanced Renal Failure
Current Medicinal Chemistry In Vitro and In Vivo Performance of Novel Spray Dried Andrographolide Loaded Scleroglucan Based Formulation for Dry Powder Inhaler
Current Drug Delivery Nicotinamide Adenine Dinucleotide Based Therapeutics
Current Medicinal Chemistry p53-Induced Apoptosis and Inhibitors of p53
Current Medicinal Chemistry Three Decades of P-gp Inhibitors: Skimming Through Several Generations and Scaffolds
Current Medicinal Chemistry ABC Transporters in Multidrug Resistance and Pharmacokinetics, and Strategies for Drug Development
Current Pharmaceutical Design Different Concepts of Drug Delivery in Disease Entities
Mini-Reviews in Medicinal Chemistry Protein Kinases as Drug Targets in Cancer
Current Cancer Drug Targets Ligands of Diltiazem Binding Site: An Overview of Some Chemotypes
Mini-Reviews in Medicinal Chemistry Protective Effects of Dietary Flavonoids in Diabetic Induced Retinal Neurodegeneration
Current Drug Targets Is There a Role for Antioxidants in the Prevention of Infection-Associated Carcinogenesis and in the Treatment of Infection-Driven Tumors?
Current Topics in Medicinal Chemistry The Association of Collagenase with Human Diseases and its Therapeutic Potential in Overcoming them
Current Biotechnology Linezolid Activity Against Disseminated Listeria monocytogenes Meningitis and Central Nervous System Abscesses: Focus on Early Drug Myelotoxicity
Current Drug Safety Current Status and Future Perspectives of PI3K and mTOR Inhibitor as Anticancer Drugs in Breast Cancer
Current Cancer Drug Targets Maternal Dyslipidaemia in Pregnancy with Gestational Diabetes Mellitus: Possible Impact on Foetoplacental Vascular Function and Lipoproteins in the Neonatal Circulation
Current Vascular Pharmacology