Abstract
Dementia is an acquired progressive cognitive dysfunction, affecting the content of consciousness rather than the level of consciousness. Most dementia is senile dementia, accounting for the majority of dementia. The most important and common form of senile dementia is refractory dementia, which includes Alzheimer's disease (AD) and vascular dementia (VD). Due to the diversity and uncertainty of the pathogenic mechanism of VD and AD, no significantly effective drug currently exists. Berberine is a natural isoquinoline alkaloid extracted from Coptis chinensis that has a wide range of pharmacological effects. studies in recent years have also found that berberine can additionally treat senile dementia by affecting neurotransmitter, anti-oxidative stress, metabolism and other multi-target pathways. Multi-target treatment of senile dementia by berberine is a potential avenue of study for senile dementia treatment.
Keywords: Berberine, Senile dementia, Vascular dementia, Alzheimer's disease, Multi-target.
Current Topics in Medicinal Chemistry
Title:The Role of Berberine in the Multi-Target Treatment of Senile Dementia
Volume: 16 Issue: 8
Author(s): Min Huang, Siyan Chen, Yubin Liang and Yi Guo
Affiliation:
Keywords: Berberine, Senile dementia, Vascular dementia, Alzheimer's disease, Multi-target.
Abstract: Dementia is an acquired progressive cognitive dysfunction, affecting the content of consciousness rather than the level of consciousness. Most dementia is senile dementia, accounting for the majority of dementia. The most important and common form of senile dementia is refractory dementia, which includes Alzheimer's disease (AD) and vascular dementia (VD). Due to the diversity and uncertainty of the pathogenic mechanism of VD and AD, no significantly effective drug currently exists. Berberine is a natural isoquinoline alkaloid extracted from Coptis chinensis that has a wide range of pharmacological effects. studies in recent years have also found that berberine can additionally treat senile dementia by affecting neurotransmitter, anti-oxidative stress, metabolism and other multi-target pathways. Multi-target treatment of senile dementia by berberine is a potential avenue of study for senile dementia treatment.
Export Options
About this article
Cite this article as:
Huang Min, Chen Siyan, Liang Yubin and Guo Yi, The Role of Berberine in the Multi-Target Treatment of Senile Dementia, Current Topics in Medicinal Chemistry 2016; 16 (8) . https://dx.doi.org/10.2174/1568026615666150827095433
DOI https://dx.doi.org/10.2174/1568026615666150827095433 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Chemistry Based on Natural Products for Therapeutic Purposes
The development of new pharmaceuticals for a wide range of medical conditions has long relied on the identification of promising natural products (NPs). There are over sixty percent of cancer, infectious illness, and CNS disease medications that include an NP pharmacophore, according to the Food and Drug Administration. Since NP ...read more
Current Trends in Drug Discovery Based on Artificial Intelligence and Computer-Aided Drug Design
Drug development discovery has faced several challenges over the years. In fact, the evolution of classical approaches to modern methods using computational methods, or Computer-Aided Drug Design (CADD), has shown promising and essential results in any drug discovery campaign. Among these methods, molecular docking is one of the most notable ...read more
Drug Discovery in the Age of Artificial Intelligence
In the age of artificial intelligence (AI), we have witnessed a significant boom in AI techniques for drug discovery. AI techniques are increasingly integrated and accelerating the drug discovery process. These developments have not only attracted the attention of academia and industry but also raised important questions regarding the selection ...read more
From Biodiversity to Chemical Diversity: Focus of Flavonoids
Flavonoids are the largest group of polyphenols, plant secondary metabolites arising from the essential aromatic amino acid phenylalanine (or more rarely from tyrosine) via the phenylpropanoid pathway. The flavan nucleus is the basic 15-carbon skeleton of flavonoids (C6-C3-C6), which consists of two phenyl rings (A and B) and a heterocyclic ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Spatio-Temporal Fluctuations of Neural Dynamics in Mild Cognitive Impairment and Alzheimer’s Disease
Current Alzheimer Research Fibrin Clot Properties and Cardiovascular Disease
Vascular Disease Prevention (Discontinued) A Review: Natural Compounds as Anti-Alzheimer´s Disease Agents
Current Nutrition & Food Science Protective Effects of Melatonin and Mitochondria-targeted Antioxidants Against Oxidative Stress: A Review
Current Medicinal Chemistry Alzheimer's disease: Targeting the Cholinergic System
Current Neuropharmacology Therapeutic Approaches for Lysosomal Storage Diseases: A Patent Update
Recent Patents on CNS Drug Discovery (Discontinued) Vascular Risk Factors and Neurodegeneration in Ageing Related Dementias: Alzheimer’s Disease and Vascular Dementia
Current Alzheimer Research Role of Gut Microbiota in Obesity, Type 2 Diabetes and Alzheimer’s Disease
CNS & Neurological Disorders - Drug Targets Editorial (Hot Topic: Organic Solute Transporters and Diseases: Potential Therapeutic Targets)
Current Molecular Pharmacology Dietary Approaches and Supplements in the Prevention of Cognitive Decline and Alzheimer's Disease
Current Pharmaceutical Design Traumatic Brain Injury as a Risk Factor for Alzheimer’s Disease: Is Inflammatory Signaling a Key Player?
Current Alzheimer Research The Early Involvement of the Innate Immunity in the Pathogenesis of Lateonset Alzheimers Disease: Neuropathological, Epidemiological and Genetic Evidence
Current Alzheimer Research Comparative Effectiveness of Agmatine and Choline Treatment in Rats with Cognitive Impairment Induced by AlCl<sub>3</sub> and Forced Swim Stress
Current Clinical Pharmacology Nocturnal Hypertension, Nondipping Phenomenon and Target Organ Damage in Obstructive Sleep Apnea Patients - The Bad and the Worse
Current Respiratory Medicine Reviews Oxidative Stress Correlates (OSC) in Diabetes Mellitus Patients
Current Diabetes Reviews Artery of Percheron Infarction: A Characteristic Pattern of Ischemia and Variable Clinical Presentation: A Literature Review
Current Medical Imaging Platelets in Rheumatic Diseases: Friend or Foe?
Current Pharmaceutical Design Synthesis, Characterization and Potential Applications of Multifunctional PEO-PPOPEO- Magnetic Drug Delivery System
Current Medicinal Chemistry NAD in Skin: Therapeutic Approaches for Niacin
Current Pharmaceutical Design Therapeutic Perspectives of Drugs Targeting Toll-Like Receptors Based on Immune Physiopathology Theory of Alzheimers Disease
CNS & Neurological Disorders - Drug Targets