Abstract
Epilepsy is one of the most common neurological disorders in humans, and the role of cerebellum in its physiopathology remains the subject of study. Bergmann glia in the cerebellar cortex regulates the homeostasis of Purkinje cells, the axons of which target the dentate and interpositus nuclei, which form the main cerebellar output to other structures in the central nervous system involved in Epilepsy. Sox-1 is a transcription factor expressed in Bergmann glia and its binding to β-Catenin further inhibits the Wnt pathway. β-Catenin is widely expressed in cerebellum. It has been reported that β-Catenin signaling is increased as the hippocampus receives repeated electrical stimuli and this is related with apoptosis of neurons. In the cerebellum, the recurrence of seizures results in Purkinje cells death, although the mechanisms remain unclear.
Keywords: Epilepsy, Cerebellum, Bergmann glia, Sox-1, β-catenin, Apoptosis.
CNS & Neurological Disorders - Drug Targets
Title:Commentary: Participation of Sox-1 Expression and Signaling of β-Catenin in the Pathophysiology of Generalized Seizures in Cerebellum of Rat
Volume: 15 Issue: 1
Author(s): Artemio Rosiles, Carmen Rubio, Cristina Trejo, Jessica Gutierrez, Leonardo Hernández and Carlos Paz
Affiliation:
Keywords: Epilepsy, Cerebellum, Bergmann glia, Sox-1, β-catenin, Apoptosis.
Abstract: Epilepsy is one of the most common neurological disorders in humans, and the role of cerebellum in its physiopathology remains the subject of study. Bergmann glia in the cerebellar cortex regulates the homeostasis of Purkinje cells, the axons of which target the dentate and interpositus nuclei, which form the main cerebellar output to other structures in the central nervous system involved in Epilepsy. Sox-1 is a transcription factor expressed in Bergmann glia and its binding to β-Catenin further inhibits the Wnt pathway. β-Catenin is widely expressed in cerebellum. It has been reported that β-Catenin signaling is increased as the hippocampus receives repeated electrical stimuli and this is related with apoptosis of neurons. In the cerebellum, the recurrence of seizures results in Purkinje cells death, although the mechanisms remain unclear.
Export Options
About this article
Cite this article as:
Rosiles Artemio, Rubio Carmen, Trejo Cristina, Gutierrez Jessica, Hernández Leonardo and Paz Carlos, Commentary: Participation of Sox-1 Expression and Signaling of β-Catenin in the Pathophysiology of Generalized Seizures in Cerebellum of Rat, CNS & Neurological Disorders - Drug Targets 2016; 15 (1) . https://dx.doi.org/10.2174/1871527314666150821105001
DOI https://dx.doi.org/10.2174/1871527314666150821105001 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
Call for Papers in Thematic Issues
Diagnosis and treatment of central nervous system infectious diseases
Infectious diseases of the central nervous system (CNS) can be divided into bacterial, tuberculous, viral, fungal, parasitic infections, etc. Early etiological treatment is often the most crucial means to reduce the mortality rate of patients with central nervous system infections, reduce complications and sequelae, and improve prognosis. The initial clinical ...read more
Techniques of Drug Repurposing: Delivering a new life to Herbs & Drugs
Of late, with the adaptation of innovative approaches and integration of advancements made towards medical sciences as well as the availability of a wide range of tools; several therapeutic challenges are being translated into viable clinical solutions, with a high degree of efficacy, safety, and selectivity. With a better understanding ...read more
Trends and perspectives in the rational management of CNS disorders
Central nervous system (CNS) diseases enforce a significant global health burden, driving ongoing efforts to improve our understanding and effectiveness of therapy. This issue investigates current advances in the discipline, focusing on the understanding as well as therapeutic handling of various CNS diseases. The issue covers a variety of diseases, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
A Very Rare Cerebral Complication of Chemotherapy in a Young Girl: A Difficult Diagnosis
Current Drug Safety On the Discovery and Development of CFTR Chloride Channel Activators
Current Pharmaceutical Design Editorial (Thematic Issue: Global Trends for Nanotechnological Approaches in Various Health Issues - Part 1)
Current Drug Metabolism Dietary Approaches and Supplements in the Prevention of Cognitive Decline and Alzheimer's Disease
Current Pharmaceutical Design Development and Validation of a Fluorescence-Based HTS Assay for the Identification of P/Q-Type Calcium Channel Blockers
Combinatorial Chemistry & High Throughput Screening Managing Expectations in the Transition to Proof of Concept Studies
Reviews on Recent Clinical Trials HtrA Serine Proteases as Potential Therapeutic Targets in Cancer
Current Cancer Drug Targets Dry Age-Related Macular Degeneration: Recent Progress of Therapeutic approaches
Current Molecular Pharmacology Adiponectin and its Role in Cardiovascular Diseases
Cardiovascular & Hematological Disorders-Drug Targets L-Type Calcium Channels
Current Pharmaceutical Design Bryostatin-1 Synergizes with Histone Deacetylase Inhibitors to Reactivate HIV-1 from Latency
Current HIV Research Neuroprotective Properties of Peroxisome Proliferator-Activated Receptor Alpha (PPARα) and its Lipid Ligands
Current Medicinal Chemistry Imaging of P-glycoprotein Function and Expression to Elucidate Mechanisms of Pharmacoresistance in Epilepsy
Current Topics in Medicinal Chemistry Novel Therapeutic Strategies for Dementia
CNS & Neurological Disorders - Drug Targets Somatostatin and Cognitive Function in Neurodegenerative Disorders
Mini-Reviews in Medicinal Chemistry Biomarkers of Alzheimer’s Disease: An Overview of the Recent Inventions
Recent Patents on Biomarkers Is Going for Cure in CML Targeting Aberrant Glycogen Synthase Kinase 3β?
Current Drug Targets Preclinical Analyses of the Therapeutic Potential of Allopregnanolone to Promote Neurogenesis In Vitro and In Vivo in Transgenic Mouse Model of Alzheimers Disease
Current Alzheimer Research New Medical Strategies for Midgut Carcinoids
Anti-Cancer Agents in Medicinal Chemistry From Discovery to Clinical Trials: Treatment Strategies for Central Neuropathic Pain after Spinal Cord Injury
Current Pharmaceutical Design