Abstract
The essential oil of Callitris intratropica is composed to a considerable proportion of rather unique lactones like callitrin (I), callitrisin (II) and columellarin (III) (Fig. 1) [1-7]. During the investigation of the volatiles obtained by hydrodistillation of the wood of this Cupressaceae species [8] we noticed that the oil yield increases with distillation time while the oil composition is shifted more and more towards the high boiling components. To find the reason for this behavior some wood was extracted in a Soxhlet apparatus and the resulting red-brown resinous oil analyzed by GC-MS-FID on a short GC column. The lignans deoxypodorhizon (IV) and deoxypodophyllotoxin (V) [9 -11] were disclosed and present in rather large amounts. Since the wood is available in large quantities this finding points out a new rich source [12 - 14] of these potent bioactive lignans.
Keywords: Callitris intratropica, ethanol extract, chemical composition, lignans, deoxypodophyllotoxin, deoxypodorhizon.
Current Bioactive Compounds
Title:Callitris intratropica R.T. Baker & H.G. Smith as a Novel Rich Source of Deoxypodophyllotoxin
Volume: 11 Issue: 2
Author(s): Juergen Wanner, Leopold Jirovetz and Erich Schmidt
Affiliation:
Keywords: Callitris intratropica, ethanol extract, chemical composition, lignans, deoxypodophyllotoxin, deoxypodorhizon.
Abstract: The essential oil of Callitris intratropica is composed to a considerable proportion of rather unique lactones like callitrin (I), callitrisin (II) and columellarin (III) (Fig. 1) [1-7]. During the investigation of the volatiles obtained by hydrodistillation of the wood of this Cupressaceae species [8] we noticed that the oil yield increases with distillation time while the oil composition is shifted more and more towards the high boiling components. To find the reason for this behavior some wood was extracted in a Soxhlet apparatus and the resulting red-brown resinous oil analyzed by GC-MS-FID on a short GC column. The lignans deoxypodorhizon (IV) and deoxypodophyllotoxin (V) [9 -11] were disclosed and present in rather large amounts. Since the wood is available in large quantities this finding points out a new rich source [12 - 14] of these potent bioactive lignans.
Export Options
About this article
Cite this article as:
Wanner Juergen, Jirovetz Leopold and Schmidt Erich, Callitris intratropica R.T. Baker & H.G. Smith as a Novel Rich Source of Deoxypodophyllotoxin, Current Bioactive Compounds 2015; 11 (2) . https://dx.doi.org/10.2174/157340721102150820124412
DOI https://dx.doi.org/10.2174/157340721102150820124412 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Chromogranin A as a Calcium-Binding Precursor for a Multitude of Regulatory Peptides for the Immune, Endocrine and Metabolic Systems
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Arsenic trioxide Alters the MicroRNA Expression Profile of U87 glioblastoma
Anti-Cancer Agents in Medicinal Chemistry Wnt / β-Catenin Signaling Pathway as Novel Cancer Drug Targets
Current Cancer Drug Targets Hydroxytyrosol Promotes Superoxide Production and Defects in Autophagy Leading to Anti-proliferation and Apoptosis on Human Prostate Cancer Cells
Current Cancer Drug Targets Novel 5-Methyl-2,4-Disubstitued-Oxazole Derivatives: Synthesis and Anticancer Activity
Letters in Drug Design & Discovery Recent Development of Copolymeric Nano-Drug Delivery System for Paclitaxel
Anti-Cancer Agents in Medicinal Chemistry Effects of Endocrine Disruptors on Developmental and Reproductive Functions
Current Drug Targets - Immune, Endocrine & Metabolic Disorders The JPJDF has Synergistic Effect with Fluoropyrimidine in the Maintenance Therapy for Metastatic Colorectal Cancer
Recent Patents on Anti-Cancer Drug Discovery Proteinases as Biomarkers in Breast Cancer Prognosis and Diagnosis
Mini-Reviews in Medicinal Chemistry Natural Products, Synthetic and Non-Nucleoside Compounds as Inhibitors of Enzymes Related to DNA: Update 2013
Current Enzyme Inhibition Caffeic Acid Phenethyl Ester Restores Adipocyte Gene Profile Expression Following Lipopolysaccharide Treatment
Letters in Drug Design & Discovery Drug Delivery Systems for the Treatment of Diabetes Mellitus: State of the Art
Current Pharmaceutical Design Cadmium as an Endocrine Disruptor in the Reproductive System
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Novel Research Strategies of Benzimidazole Derivatives: A Review
Mini-Reviews in Medicinal Chemistry Aptamers: Molecular Tools for Medical Diagnosis
Current Topics in Medicinal Chemistry Circulating microRNAs as Potential Diagnostic, Prognostic and Therapeutic Targets in Pancreatic Cancer
Current Pharmaceutical Design Sphingolipid Signaling and Hematopoietic Malignancies: To the Rheostat and Beyond
Anti-Cancer Agents in Medicinal Chemistry Estimation of Affinity of HLA-A*0201 Restricted CTL Epitope Based on the SCORE Function
Protein & Peptide Letters A Systematic Review of Genes Involved in the Inverse Resistance Relationship Between Cisplatin and Paclitaxel Chemotherapy: Role of BRCA1
Current Cancer Drug Targets Cdc20: A Potential Novel Therapeutic Target for Cancer Treatment
Current Pharmaceutical Design