Assembly of Quinoline, Triazole and Oxime Ether in a Single Molecular Entity: A Greener and One-pot Synthesis of Novel Oximes as Potential Cytotoxic Agents

Title:Assembly of Quinoline, Triazole and Oxime Ether in a Single Molecular Entity: A Greener and One-pot Synthesis of Novel Oximes as Potential Cytotoxic Agents

Volume: 13 Issue: 3

Author(s): Koduru Sri Shanthi Praveena, Edupuganti Veera Venkat Shivaji Ramarao, Yedla Poornachandra, Chityal Ganesh Kumar, Nallapati Suresh Babu, Nandula Yadagiri Sreenivasa Murthy and Sarbani Pal

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Keywords: Quinoline, 1, 2, 3-triazole, oxime, cancer, PDE4.

Abstract: An assembly of quinoline, triazole and oxime ether in a single molecular entity afforded a new template that has been used for the generation of a small library of molecules as potential cytotoxic agents. These molecules were synthesized successfully via a one pot multistep method using the copper(I)-catalyzed [3+2]-azide-alkyne cycloaddition (CuAAC) in water as the key step. All these compounds were synthesized in good to excellent yields and were screened for their inhibitory effects on the growth of four cancer cell lines in vitro. Some of these compounds showed encouraging cytotoxic effects against lung cancer cells and inhibition of PDE4 in vitro.

Cite this article as:

Shanthi Praveena Sri Koduru, Venkat Shivaji Ramarao Veera Edupuganti, Poornachandra Yedla, Kumar Ganesh Chityal, Babu Suresh Nallapati, Sreenivasa Murthy Yadagiri Nandula and Pal Sarbani, Assembly of Quinoline, Triazole and Oxime Ether in a Single Molecular Entity: A Greener and One-pot Synthesis of Novel Oximes as Potential Cytotoxic Agents, Letters in Drug Design & Discovery 2016; 13 (3) . https://dx.doi.org/10.2174/1570180812999150819095308