Abstract
A simple, straightforward and eco-friendly protocol for the synthesis of pharmaceuticallyinteresting aryl/heteroaryl-substituted bis(6-aminouracil-5-yl)methane derivatives has been developed using sulfamic acid (NH2SO3H) as a cost-effective and non-toxic organo-catalyst via pseudomulticomponent reaction of 6-amino-1,3-dimethyluracil with aromatic/heteroaromatic aldehydes in aqueous ethanol at room temperature. Mild reaction conditions, good to excellent yields, ecofriendliness, easy isolation of products and avoidance of column chromatographic separation are some of the notable features of this protocol.
Keywords: Aqueous ethanol, bis(6-aminouracil-5-yl)methanes, eco-friendly, no column chromatography, room-temperature, sulfamic acid.
Current Organocatalysis
Title:Room Temperature Metal-Free Synthesis of Aryl/Heteroaryl-Substituted Bis(6-aminouracil-5-yl)methanes Using Sulfamic Acid (NH2SO3H) as an Efficient and Eco-friendly Organo-Catalyst
Volume: 3 Issue: 2
Author(s): Bubun Banerjee and Goutam Brahmachari
Affiliation:
Keywords: Aqueous ethanol, bis(6-aminouracil-5-yl)methanes, eco-friendly, no column chromatography, room-temperature, sulfamic acid.
Abstract: A simple, straightforward and eco-friendly protocol for the synthesis of pharmaceuticallyinteresting aryl/heteroaryl-substituted bis(6-aminouracil-5-yl)methane derivatives has been developed using sulfamic acid (NH2SO3H) as a cost-effective and non-toxic organo-catalyst via pseudomulticomponent reaction of 6-amino-1,3-dimethyluracil with aromatic/heteroaromatic aldehydes in aqueous ethanol at room temperature. Mild reaction conditions, good to excellent yields, ecofriendliness, easy isolation of products and avoidance of column chromatographic separation are some of the notable features of this protocol.
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Cite this article as:
Banerjee Bubun and Brahmachari Goutam, Room Temperature Metal-Free Synthesis of Aryl/Heteroaryl-Substituted Bis(6-aminouracil-5-yl)methanes Using Sulfamic Acid (NH2SO3H) as an Efficient and Eco-friendly Organo-Catalyst, Current Organocatalysis 2016; 3 (2) . https://dx.doi.org/10.2174/2213337202666150812231130
DOI https://dx.doi.org/10.2174/2213337202666150812231130 |
Print ISSN 2213-3372 |
Publisher Name Bentham Science Publisher |
Online ISSN 2213-3380 |
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