Abstract
Chemical modification of proteins with bioorthogonal reaction and site-selectivity has been increasingly recognized for exquisite control over homogeneity and geometry, allowing more complex and various applications of proteins. The development of novel bioorthogonal reactions and their adaptation to protein chemistry in the form of genetically encoded non-natural amino acids are fueling widespread use of the so-called ‘bioorthogonal protein conjugation’. Site-specific incorporation of a non-natural amino acid technique precisely delivers a bioorthogonal group to any defined site in response to an expanded genetic code where a selective bond-forming reaction equips proteins with novel functionalities in a chemically well-defined and homogeneous manner.
Keywords: Non-natural amino acid, bioorthogonal reaction, site-specific incorporation, bioconjugation, protein evolution, genetic code.
Graphical Abstract
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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