Abstract
Background: Current HIV antiretroviral therapies potently suppress virus replication and prevent patients from progressing to AIDS but are unable to completely eliminate HIV due to the existence of dormant viral reservoirs which threaten to reemerge at anytime. Recently, genome-editing technologies that can recognize specific DNA sequences, including viral DNA, are being touted as promising tools for curing HIV, owing to their specificity, ease of use, and ability to be custom designed.
Conclusion: Here, we introduce several novel strategies aimed at eradicating HIV proviruses with state-of-the-art genomeediting technologies and discuss perspectives of these approaches for curing HIV.
Keywords: CRISPR/Cas9, genome editing, HIV, latency, provirus, TALENs, ZFNs.
Graphical Abstract
Current HIV Research
Title:Perspectives of Genome-Editing Technologies for HIV Therapy
Volume: 14 Issue: 1
Author(s): Hirotaka Ebina, Peter Gee and Yoshio Koyanagi
Affiliation:
Keywords: CRISPR/Cas9, genome editing, HIV, latency, provirus, TALENs, ZFNs.
Abstract: Background: Current HIV antiretroviral therapies potently suppress virus replication and prevent patients from progressing to AIDS but are unable to completely eliminate HIV due to the existence of dormant viral reservoirs which threaten to reemerge at anytime. Recently, genome-editing technologies that can recognize specific DNA sequences, including viral DNA, are being touted as promising tools for curing HIV, owing to their specificity, ease of use, and ability to be custom designed.
Conclusion: Here, we introduce several novel strategies aimed at eradicating HIV proviruses with state-of-the-art genomeediting technologies and discuss perspectives of these approaches for curing HIV.
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Cite this article as:
Ebina Hirotaka, Gee Peter and Koyanagi Yoshio, Perspectives of Genome-Editing Technologies for HIV Therapy, Current HIV Research 2016; 14 (1) . https://dx.doi.org/10.2174/1570162X13666150807105718
DOI https://dx.doi.org/10.2174/1570162X13666150807105718 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
Call for Papers in Thematic Issues
Management of HIV: Management of HIV: old challenges and new needs
The aim of this thematic issue is to provide the most recent updates regarding the effective management of HIV infection. Antiretroviral therapy (ART) has significantly decreased HIV-related mortality, leading to an enhancement in the quality of life and life expectancy for people living with HIV (PLWH). Despite the numerous advancements ...read more
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