Abstract
Oral cancer (OC) is a common and aggressive cancer with poor survival rate. Recent research has investigated in detail the complex network of chemical, viral, and (epi)genetic factors associated with oral carcinogenesis. However, the causal factors that trigger the oral carcinogenesis process and the molecular mechanisms that underlie the tumor progression, and metastasis of OC have not been clarified. The present study analyses the hypothesis that immune reactions following viral infections may crossreact with tumor suppressor action proteins involved in OC. Using proteome databases and epitope catalogue resources together with data derived from an ample scientific-clinical literature, potential peptide crossreactions between HCV, HPV16, EBV, and CMV pathogens and human p53 and CSMD tumor suppressor proteins are detailed. The present study might contribute to understand the molecular basis of oral carcinogenesis and open new therapeutic research perspectives.
Keywords: Epitopes, oral cancer, peptide crossreactivity, tumor suppressor proteins, viruses.
Anti-Cancer Agents in Medicinal Chemistry
Title:Viruses and Oral Cancer: Crossreactivity as a Potential Link
Volume: 15 Issue: 10
Author(s): Alberta Lucchese
Affiliation:
Keywords: Epitopes, oral cancer, peptide crossreactivity, tumor suppressor proteins, viruses.
Abstract: Oral cancer (OC) is a common and aggressive cancer with poor survival rate. Recent research has investigated in detail the complex network of chemical, viral, and (epi)genetic factors associated with oral carcinogenesis. However, the causal factors that trigger the oral carcinogenesis process and the molecular mechanisms that underlie the tumor progression, and metastasis of OC have not been clarified. The present study analyses the hypothesis that immune reactions following viral infections may crossreact with tumor suppressor action proteins involved in OC. Using proteome databases and epitope catalogue resources together with data derived from an ample scientific-clinical literature, potential peptide crossreactions between HCV, HPV16, EBV, and CMV pathogens and human p53 and CSMD tumor suppressor proteins are detailed. The present study might contribute to understand the molecular basis of oral carcinogenesis and open new therapeutic research perspectives.
Export Options
About this article
Cite this article as:
Lucchese Alberta, Viruses and Oral Cancer: Crossreactivity as a Potential Link , Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (10) . https://dx.doi.org/10.2174/1871520615666150716105654
DOI https://dx.doi.org/10.2174/1871520615666150716105654 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
Call for Papers in Thematic Issues
Induction of cell death in cancer cells by modulating telomerase activity using small molecule drugs
Telomeres are distinctive but short stretches present at the corners of chromosomes and aid in stabilizing chromosomal makeup. Resynthesis of telomeres supported by the activity of reverse transcriptase ribonucleoprotein complex telomerase. There is no any telomerase activity in human somatic cells, but the stem cells and germ cells undergone telomerase ...read more
Role of natural compounds as anti anti-cancer agents
Cancer is considered the leading cause of worldwide mortality, accounting for nearly 10 million deaths in 2022. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy remains an important approach in treatment o f several types of cancers, even though ...read more
Signaling and enzymatic modulators in cancer treatment
Cancer accounts for nearly 10 million deaths in 2022 and is considered the leading cause of worldwide mortality. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy, radiotherapy and surgery are the most important approach for the treatment of several ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Interferons: Mechanisms, Biological Activities and Survey of their Use in Human Diseases
Current Bioactive Compounds Alpha-Interferon and Its Effects on Signalling Pathways Within Cells
Current Protein & Peptide Science A General Method for the Synthesis of 3,3-bis(indol-3-yl)indolin-2-ones, bis(indol-3-yl)(aryl)methanes and tris(indol-3-yl)methanes Using Naturally Occurring Mandelic Acid as an Efficient Organo-catalyst in Aqueous Ethanol at Room Temperature
Current Green Chemistry Impact of p53 arg72pro SNP on Breast Cancer Risk in North Indian Population
Current Genomics MicroRNA in Cervical Carcinogenesis: Window of Therapeutic Potential
Current Women`s Health Reviews Effects of Tobacco Nicotine-Derived Nitrosamine Ketone (NNK) Exposures on Brain Alcohol Metabolizing Enzyme Activities
Drug Metabolism Letters Multifunctional Nanoparticles, Nanocages and Degradable Polymers as a Potential Novel Generation of Non-Invasive Molecular and Cellular Imaging Systems
Recent Patents on Nanotechnology White Poplar (Populus alba L.) Suspension Cultures as a Model System to Study Apoptosis Induced by Alfalfa Saponins
Anti-Cancer Agents in Medicinal Chemistry Gestational Trophoblastic Neoplasia, an Ancient Disease: New Light and Potential Therapeutic Targets
Anti-Cancer Agents in Medicinal Chemistry Progress in the Development of Selective Inhibitors of Aurora Kinases
Current Topics in Medicinal Chemistry Role of Unani Medicines in Cancer Control and Management
Current Drug Therapy Is Type D Personality Here to Stay? Emerging Evidence Across Cardiovascular Disease Patient Groups
Current Cardiology Reviews Inhibiting Cyclin-Dependent Kinase / Cyclin Activity for the Treatment of Cancer and Cardiovascular Disease
Current Pharmaceutical Biotechnology Curcumin: Not So Spicy After All
Mini-Reviews in Medicinal Chemistry Cordycepin Suppresses Integrin/FAK Signaling and Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma
Anti-Cancer Agents in Medicinal Chemistry HIV-1 Vpr: Enhancing Sensitivity of Tumors to Apoptosis
Current Drug Delivery Genomic Organization and Control of the Grb7 Gene Family
Current Genomics NF-κB Signaling and Carcinogenesis
Current Pharmaceutical Design Principles of Minimally Invasive Parathyroidectomy
Current Medical Imaging Back to the Future: COX-2 Inhibitors for Chemoprevention and Cancer Therapy
Mini-Reviews in Medicinal Chemistry