Abstract
The controversial point of treatment for oropharyngeal cancer is the surgical approach and it is in transition, especially for resectable tumors. Transcervical oropharyngectomy with mandibulotomy is an oncologically valid surgical option for resectable T3–T4a oropharyngeal cancers and contraindications for transoral lateral oropharyngectomy. The approach without mandibulotomy allows for simple reconstruction and has a low complication rate. In particular, it spares the patients’ morbidity related to mandibulotomy.
The transoral approach, especially with robotic surgical systems seem likely to offer an alternative approach and refinement of oropharuyngectomy in the future.
Keywords: Advanced oropharyngeal carcinoma, mandibulotomy, transcervical oropharyngectomy.
Graphical Abstract
Call for Papers in Thematic Issues
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
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