Abstract
Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in the pediatric population and recapitulates many of the phenotypic and biological features of embryonic skeletal muscle. RMS is pathologically characterized by myogenic differentiation arrest. Dysregulation of pathways essential for myogenesis like contribute to the tumorigenesis of RMS. The Wnt signaling pathway is one of the major pathways required for normal myogenesis. Aberrant Wnt signaling has also been demonstrated in many types of cancer. The role of Wnt pathway in the pathogenesis of RMS is beginning to be appreciated. This review will go over current knowledge on biological roles of Wnt pathway in RMS and potential translational application in therapeutics.
Keywords: Wnt, rhabdomyosarcoma, cancer, myogenesis.
Current Drug Targets
Title:Wnt Signaling in Rhabdomyosarcoma – A Potential Targeted Therapy Option
Volume: 17 Issue: 11
Author(s): Eleanor Chen
Affiliation:
Keywords: Wnt, rhabdomyosarcoma, cancer, myogenesis.
Abstract: Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in the pediatric population and recapitulates many of the phenotypic and biological features of embryonic skeletal muscle. RMS is pathologically characterized by myogenic differentiation arrest. Dysregulation of pathways essential for myogenesis like contribute to the tumorigenesis of RMS. The Wnt signaling pathway is one of the major pathways required for normal myogenesis. Aberrant Wnt signaling has also been demonstrated in many types of cancer. The role of Wnt pathway in the pathogenesis of RMS is beginning to be appreciated. This review will go over current knowledge on biological roles of Wnt pathway in RMS and potential translational application in therapeutics.
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Cite this article as:
Chen Eleanor, Wnt Signaling in Rhabdomyosarcoma – A Potential Targeted Therapy Option, Current Drug Targets 2016; 17 (11) . https://dx.doi.org/10.2174/1389450116666150630110625
DOI https://dx.doi.org/10.2174/1389450116666150630110625 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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