Abstract
Synthesis of cross-linkable diketopiperadine derivatives is described. Cross-linkable aamino acid methyl esters were subjected to peptide synthesis with Boc-protected glycine or L-tyrosine. No protection of cross-linkable functional groups (catechol and phenylazide) is necessary for the construction of diketopiperazine skeleton.
Keywords: Cross-link, cyclic dipeptide, diketopiperazine, DOPA, phenylazide, photoaffinity label.
Letters in Organic Chemistry
Title:Synthesis of Cross-linkable 2,5-Diketopiperazine Derivatives
Volume: 12 Issue: 8
Author(s): Takuma Yoshida, Lei Wang, Shiori Nakagawa, Zetryana Puteri Tachrim, Yasuko Sakihama, Yasuyuki Hashidoko and Makoto Hashimoto
Affiliation:
Keywords: Cross-link, cyclic dipeptide, diketopiperazine, DOPA, phenylazide, photoaffinity label.
Abstract: Synthesis of cross-linkable diketopiperadine derivatives is described. Cross-linkable aamino acid methyl esters were subjected to peptide synthesis with Boc-protected glycine or L-tyrosine. No protection of cross-linkable functional groups (catechol and phenylazide) is necessary for the construction of diketopiperazine skeleton.
Export Options
About this article
Cite this article as:
Yoshida Takuma, Wang Lei, Nakagawa Shiori, Tachrim Puteri Zetryana, Sakihama Yasuko, Hashidoko Yasuyuki and Hashimoto Makoto, Synthesis of Cross-linkable 2,5-Diketopiperazine Derivatives, Letters in Organic Chemistry 2015; 12 (8) . https://dx.doi.org/10.2174/1570178612666150629181357
DOI https://dx.doi.org/10.2174/1570178612666150629181357 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Co-medications and Drug-Drug Interactions in People Living with HIV in Turkey in the Era of Integrase Inhibitors
Current HIV Research Trypanocidal Activity of Nitroaromatic Prodrugs: Current Treatments and Future Perspectives
Current Topics in Medicinal Chemistry Current Technology in the Discovery and Development of Novel Antibacterials
Current Drug Targets Graphical Abstracts:
Letters in Drug Design & Discovery Nanoparticles for Cancer Targeting: Current and Future Directions
Current Drug Delivery New Pyrrole Hydrazones Synthesized and Evaluated In Vitro as Potential Tuberculostatics
Letters in Drug Design & Discovery Genomics and the Prospects for the Discovery of New Targets for Antibacterial and Antifungal Agents
Current Pharmaceutical Design Chylothorax
Current Respiratory Medicine Reviews The Rhesus Macaque Pediatric SIV Infection Model - A Valuable Tool in Understanding Infant HIV-1 Pathogenesis and for Designing Pediatric HIV-1 Prevention Strategies
Current HIV Research Drug Design for Neglected Disease in Brazil
Mini-Reviews in Medicinal Chemistry Molecular Properties Prediction and Synthesis of Novel Pyrazoline Carboxamide Analogs as Antitubercular Agents
Anti-Infective Agents A Mathematical Approach for the Simultaneous In Vitro Spectrophotometric Analysis of Rifampicin and Isoniazid from Modified-Release Anti-TB Drug Delivery Systems
Current Drug Delivery Lactoferrin as a Natural Immune Modulator
Current Pharmaceutical Design Recent Advances in New Structural Classes of Anti-Tuberculosis Agents
Current Medicinal Chemistry Tuberculous Pericarditis
Current Cardiology Reviews QSAR Models for Anti-Malarial Activity of 4-Aminoquinolines
Current Computer-Aided Drug Design Recurrent Episodes of Pericardial Effusion as Isolated Manifestation of Tuberculosis: Case Report
Current Medical Imaging Novel Dibenzothiepins with Antibiofilm Activity Demonstrated by Microbiological Assays and Molecular Modeling
Current Organic Chemistry Patent Selections
Recent Patents on Anti-Infective Drug Discovery Graphical Abstracts
Letters in Drug Design & Discovery