Selective Synthesis ofβ-Lactams via Catalytic Metal Carbene C-H Insertion Reactions

Title:Selective Synthesis ofβ-Lactams via Catalytic Metal Carbene C-H Insertion Reactions

Volume: 20 Issue: 1

Author(s): Kuiyong Dong, Lihua Qiu and Xinfang Xu

Affiliation:

Keywords: Selective synthesis, β-lactams, diazo compounds, metal carbene/carbenoid, C-H insertion, buchner reaction, aromatic substitution, asymmetric catalysis.

Abstract: β-Lactam, with its unique four-membered ring structure, is an irreplaceable motif in antibacterial medicines, and the diversity synthesis of monocyclic β-lactam becomes a very effective approach for the discovery of new pharmacological properties and bioactivities. During the last few decades, efforts have been spent on the chemical synthesis of β-lactams, including approaches via metal catalysis and organocatalysis. In this review, progresses in catalytic intramolecular metal carbene insertion reaction for the β-lactams structure construction during the last two decades are demonstrated, which emphasize the chemo-, diastereo- and enantioselectivity advances in these transformations of diazo compounds with structural diversity. And a few of selected initial researches led to significant advances are also mentioned in this article.

Cite this article as:

Dong Kuiyong, Qiu Lihua and Xu Xinfang, Selective Synthesis ofβ-Lactams via Catalytic Metal Carbene C-H Insertion Reactions, Current Organic Chemistry 2016; 20 (1) . https://dx.doi.org/10.2174/1385272819666150626183713