Self-assembling Peptide Nanofibers Containing D-amino Acids for Tetrandrine Delivery

Title:Self-assembling Peptide Nanofibers Containing D-amino Acids for Tetrandrine Delivery

Volume: 10 Issue: 2

Author(s): Qian Liu, Xiaoyong Yi and Xiaomeng Hu

Affiliation:

Keywords: D-Amino acid, drug carrier, drug delivery, peptide, self-assembly, tetrandrine.

Abstract: Self-assembling peptides have very recently emerged as a new class of drug vehicles, as they hold unique advantages such as good biocompatibility, design flexibility, and controllable nanotructure. In this work, we report a self-assembling peptide containing D-amino acids (Nap- G^DF^DF^DYGRGD) as the carrier of anticancer drug tetrandrine. Tetrandrine is a bis-benzylisoquinoline alkaloid isolated from the root of Hang-Fang-Chi (Stephania tetrandra S. Moore). The D-peptides were employed in this study as they have shown stronger resistance against proteases than their Lcounterpart with natural L-amino acids. The Nap-G^DF^DF^DYGRGD peptides can self-assemble into nanofibers, which are able to efficiently encapsulate tetrandrine. The drug-loaded nanofibers are capable of sustained release of tetrandrine and being internalized by the LoVo cancer cells. The cytotoxicity studies indicate that the tetrandrine-loaded nanofibers possess similar cytotoxicity to free tetrandrine against LoVo cancer cells and the Nap- G^DF^DF^DYGRGD nanofibers can be used as a safe vehicle.

Cite this article as:

Liu Qian, Yi Xiaoyong and Hu Xiaomeng, Self-assembling Peptide Nanofibers Containing D-amino Acids for Tetrandrine Delivery, Current Signal Transduction Therapy 2015; 10 (2) . https://dx.doi.org/10.2174/1574362410666150625190853