A Novel Triazole Nucleoside Suppresses Prostate Cancer Cell Growth by Inhibiting Heat Shock Factor 1 and Androgen Receptor

Title:A Novel Triazole Nucleoside Suppresses Prostate Cancer Cell Growth by Inhibiting Heat Shock Factor 1 and Androgen Receptor

Volume: 15 Issue: 10

Author(s): Yi Xia, Menghua Wang, Eliana Beraldi, Mei Cong, Amina Zoubeidi, Martin Gleave and Ling Peng

Affiliation:

Keywords: Androgen receptor, anticancer activity, heat shock proteins, heat shock factor 1, nucleoside analogues, prostate cancer.

Abstract: A novel triazole nucleoside analogue was discovered to exhibit potent anticancer activity in prostate cancer cells via down-regulating heat shock factor 1 (HSF1) and related heat shock proteins, along with the consequential inhibition of androgen receptor (AR) expression and transactivation, arresting the cell cycle in AR-governed phase. This triazole nucleoside therefore constitutes a novel structural paradigm and potential drug candidate for prostate cancer through inhibition of HSF1 and AR.

Cite this article as:

Xia Yi, Wang Menghua, Beraldi Eliana, Cong Mei, Zoubeidi Amina, Gleave Martin and Peng Ling, A Novel Triazole Nucleoside Suppresses Prostate Cancer Cell Growth by Inhibiting Heat Shock Factor 1 and Androgen Receptor, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (10) . https://dx.doi.org/10.2174/1871520615666150617110943