Abstract
4EGI-1 is the prototype of a novel class of anticancer agents targeting translation. Patented drug-like analogue 1 was synthesized and examined for inhibition of translation and cytotoxicity in cancer cells. Unexpectedly, 1 was found inactive in both assays.
Keywords: Cancer, eIF4E, metastatic melanoma, mRNA translation, protein synthesis, thiazoles.
Anti-Cancer Agents in Medicinal Chemistry
Title:Revision of the Synthesis and Pharmacological Activity of a Reported Translation Inhibitor
Volume: 15 Issue: 10
Author(s): Christine Basmadjian, Helene Malka-Mahieu and Laurent Desaubry
Affiliation:
Keywords: Cancer, eIF4E, metastatic melanoma, mRNA translation, protein synthesis, thiazoles.
Abstract: 4EGI-1 is the prototype of a novel class of anticancer agents targeting translation. Patented drug-like analogue 1 was synthesized and examined for inhibition of translation and cytotoxicity in cancer cells. Unexpectedly, 1 was found inactive in both assays.
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Basmadjian Christine, Malka-Mahieu Helene and Desaubry Laurent, Revision of the Synthesis and Pharmacological Activity of a Reported Translation Inhibitor, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (10) . https://dx.doi.org/10.2174/1871520615666150602092450
DOI https://dx.doi.org/10.2174/1871520615666150602092450 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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