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Current Stem Cell Research & Therapy

Editor-in-Chief

ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

Stem cells contributing to postnatal skeletogenesis in the mouse bone marrow

Author(s): Peng Deng, Xiaoping Xu and Qianming Chen

Volume 10, Issue 5, 2015

Page: [450 - 456] Pages: 7

DOI: 10.2174/1574888X10666150519093626

Price: $65

Abstract

Postnatal skeletogenesis is a highly regulated process that subpopulations of bone marrow stem cells differentiate into mature skeletal tissues to maintain and repair the postnatal skeletons. Based on their skeletogenic capacity, purified bone marrow stem cells have been used to repair and replace damaged skeletal tissues in recent years. In the meantime, significant effort has been devoted to unveil the nature and function of the “skeletogenic” precursors in vivo. In this review, we summarized our current understanding of the identification and fate-mapping of the stem cells contributing to postnatal skeletogenesis in the mouse bone marrow.

Keywords: Fate-mapping, mesenchymal stem cells, multipotency, osteochondroreticular stem cells, postnatal skeletogenesis, transplantation.


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