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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

PPARδ Signaling Regulates Colorectal Cancer

Author(s): Mengli You, Shuping Yuan, Juanjuan Shi and Yongzhong Hou

Volume 21, Issue 21, 2015

Page: [2956 - 2959] Pages: 4

DOI: 10.2174/1381612821666150514104035

Price: $65

Abstract

Peroxisome proliferator-activated receptorδ (PPARδ) belongs to the PPARs receptor family including PPARα, PPARδ, and PPARγ. PPARδ is a ligand-activated transcription factor that plays a critical role in regulating cancer progression. PPARδ-linked tumorigenesis was first identified in colorectal cancer, which is demonstrated by the following evidences, so PPARε is a potential drug target for colorectal cancer. In contrast, some observations show that PPARδ negatively regulates colorectal cancer event. In the present review, the recent progress of PPARδ signaling-mediated colorectal cancer is covered.

Keywords: Colorectal cancer, PPARδ, signaling.


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