Abstract
Voltage-gated Na and Ca2+ channels represent two major ion channel families that enable myriad biological functions including the generation of action potentials and the coupling of electrical and chemical signaling in cells. Calmodulin regulation (calmodulation) of these ion channels comprises a vital feedback mechanism with distinct physiological implications. Though long-sought, a shared understanding of the channel families remained elusive for two decades as the functional manifestations and the structural underpinnings of this modulation often appeared to diverge. Here, we review recent advancements in the understanding of calmodulation of Ca2+ and Na channels that suggest a remarkable similarity in their regulatory scheme. This interrelation between the two channel families now paves the way towards a unified mechanistic framework to understand vital calmodulin-dependent feedback and offers shared principles to approach related channelopathic diseases. An exciting era of synergistic study now looms.
Keywords: Sodium channels, calcium channels, calmodulation.
Current Molecular Pharmacology
Title:Towards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium Channels
Volume: 8
Author(s): Shin Rong Lee, David T. Yue, Daniel N. Yue, Rosy Joshi-Mukherjee, Paul J. Adams, Hojjat Bazzazi, Philemon S. Yang, Manning Zhang, Jiangyu Li, Ho Namkung, Manu Ben-Johny, John B. Issa, Jennifer S. Babich, Wanjun Yang, Rahul Banerjee, Jacqueline Niu, Po Wei Kang, Worawan B. Limpitikul, Lingjie Sang and Ivy E. Dick
Affiliation:
Keywords: Sodium channels, calcium channels, calmodulation.
Abstract: Voltage-gated Na and Ca2+ channels represent two major ion channel families that enable myriad biological functions including the generation of action potentials and the coupling of electrical and chemical signaling in cells. Calmodulin regulation (calmodulation) of these ion channels comprises a vital feedback mechanism with distinct physiological implications. Though long-sought, a shared understanding of the channel families remained elusive for two decades as the functional manifestations and the structural underpinnings of this modulation often appeared to diverge. Here, we review recent advancements in the understanding of calmodulation of Ca2+ and Na channels that suggest a remarkable similarity in their regulatory scheme. This interrelation between the two channel families now paves the way towards a unified mechanistic framework to understand vital calmodulin-dependent feedback and offers shared principles to approach related channelopathic diseases. An exciting era of synergistic study now looms.
Export Options
About this article
Cite this article as:
Rong Lee Shin, T. Yue David, N. Yue Daniel, Joshi-Mukherjee Rosy, J. Adams Paul, Bazzazi Hojjat, S. Yang Philemon, Zhang Manning, Li Jiangyu, Namkung Ho, Ben-Johny Manu, B. Issa John, S. Babich Jennifer, Yang Wanjun, Banerjee Rahul, Niu Jacqueline, Wei Kang Po, B. Limpitikul Worawan, Sang Lingjie and E. Dick Ivy, Towards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium Channels, Current Molecular Pharmacology 2015; 8 (2) . https://dx.doi.org/10.2174/1874467208666150507110359
DOI https://dx.doi.org/10.2174/1874467208666150507110359 |
Print ISSN 1874-4672 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-4702 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Inhibition of Monoamine Neurotransmitter Transporters and Central Nervous System Stimulation Induced by Synthetic Local Anesthetics and Cocaine: A Comparative Review-Update
Current Medicinal Chemistry - Central Nervous System Agents Combating Diseases with Computational Strategies Used for Drug Design and Discovery
Current Topics in Medicinal Chemistry Current Developments of Coumarin Compounds in Medicinal Chemistry
Current Pharmaceutical Design Benzothiazoles - Scaffold of Interest for CNS Targeted Drugs
Current Medicinal Chemistry Characterization of the Early CNS Stress Biomarkers and Profiles Associated with Neuropsychiatric Diseases
Current Genomics In Vitro Evaluation of Potential Hepatotoxicity Induced by Drugs
Current Pharmaceutical Design Pregabalin Induced Maculopapular Eruption in an Elderly Male
Current Drug Safety Status Analysis of Herbal Drug Therapies in Epilepsy: Advancements in the Use of Medicinal Plants with Anti-inflammatory Properties
Combinatorial Chemistry & High Throughput Screening Anti-NMDA Receptor Encephalitis in Psychiatry
Current Psychiatry Reviews Potassium Channels in Peripheral Pain Pathways: Expression, Function and Therapeutic Potential
Current Neuropharmacology The Inhibitory Neural Circuitry as Target of Antiepileptic Drugs
Current Medicinal Chemistry Genetic and Environmental Factors in Complex Neurodevelopmental Disorders
Current Genomics Human Microdialysis
Current Pharmaceutical Biotechnology Selenium Deficiency in Soils and Crops and its Impact on Animal and Human Health
Current Nutrition & Food Science On the Relationship Between the Light/Dark Cycle, Melatonin and Oxidative Stress
Current Pharmaceutical Design Potassium Channel Blockers and Openers as CNS Neurologic Therapeutic Agents
Recent Patents on CNS Drug Discovery (Discontinued) Cholesterol and Apoe: A Target for Alzheimers Disease Therapeutics
Current Drug Targets - CNS & Neurological Disorders Ion Channel Modulation as a Therapeutic Approach in Multiple Sclerosis
Current Medicinal Chemistry Propitious Profile of Peppery Piperine
Current Molecular Pharmacology Mevalonate Cascade and Neurodevelopmental and Neurodegenerative Diseases: Future Targets for Therapeutic Application
Current Molecular Pharmacology