Abstract
In this study, we report the synthesis and application of the novel cyclometallated luminescent Ir(III) complex 1 bearing the C^C^C ligand as a probe and inhibitor of Aβ fibrillation. We envisage that this kinetically-inert Ir(III) complex may be potentially developed as a dual-purpose probe and inhibitor of Aβ aggregation for Alzheimer’s disease diagnosis and treatment.
Keywords: Amyloid, aggregation, Alzheimer's, luminescent probe, iridium.
Current Alzheimer Research
Title:Dual Inhibition and Monitoring of Beta-Amyloid Fibrillation by a Luminescent Iridium(III) Complex
Volume: 12 Issue: 5
Author(s): Chun-Yuen Wong, Lai-Hon Chung, Lihua Lu, Modi Wang, Bingyong He, Li-Juan Liu, Chung-Hang Leung and Dik-Lung Ma
Affiliation:
Keywords: Amyloid, aggregation, Alzheimer's, luminescent probe, iridium.
Abstract: In this study, we report the synthesis and application of the novel cyclometallated luminescent Ir(III) complex 1 bearing the C^C^C ligand as a probe and inhibitor of Aβ fibrillation. We envisage that this kinetically-inert Ir(III) complex may be potentially developed as a dual-purpose probe and inhibitor of Aβ aggregation for Alzheimer’s disease diagnosis and treatment.
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Cite this article as:
Wong Chun-Yuen, Chung Lai-Hon, Lu Lihua, Wang Modi, He Bingyong, Liu Li-Juan, Leung Chung-Hang and Ma Dik-Lung, Dual Inhibition and Monitoring of Beta-Amyloid Fibrillation by a Luminescent Iridium(III) Complex, Current Alzheimer Research 2015; 12 (5) . https://dx.doi.org/10.2174/1567205012666150504144558
DOI https://dx.doi.org/10.2174/1567205012666150504144558 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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