Abstract
To investigate the beneficial effect of L-arginine and selenium along with hypocaloric diet on metabolic features, insulin resistance and hepatic function tests this study were conducted on women with central obesity. The randomized, double-blind, placebo-controlled trial was undertaken among 68 premenopausal women with central obesity. After 2 weeks of run-in period of an isocaloric diet, participants were randomly assigned into four groups of hypocaloric control diet (HCD), Larginine (5 g / d) + HCD, selenium (200 µg / d) + HCD, or L-arginine + selenium + HCD for 6 weeks. The following variables were assessed at baseline (start of intervention) and 3 and 6 weeks after intervention: Waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting serum concentrations of triglyceride (TG), High-density lipoprotein-cholestrol (HDL-C), fasting blood sugar (FBS), insulin, homeostasis model of insulin resistance (HOMA-IR), alanine aminotransferase (ALT) and aspartat aminotransferase (AST). When t-test was used for data analysis, HCD reduced SBP (P = 0.009) and TG (P = 0.05); HCD + L-arginine reduced WC more than HCD (P = 0.008); HCD + Selenium reduced fasting serum concentration of ALT (P = 0.007); and selenium reduced fasting serum concentrations of insulin (P = 0.05) and HOMA - IR (P = 0.04), after 6 weeks of interventions. The study showed beneficial effects of L-arginine on central obesity, selenium on insulin resistance and hepatic function and HCD on blood pressure and serum lipid profile.
Keywords: Central obesity, hypocaloric diet, insulin resistance, L-arginine, metabolic syndrome, selenium.
Call for Papers in Thematic Issues
Functional Foods in Human Health and Beyond
Foods are important source of nutrients including carbohydrates, proteins, lipids and other minerals. Furthermore, the functional foods are those agents that have additional components that are essential supports to the body in terms of antioxidant and pharmacologically active agents. The predominant functional foods are of plant in origin, whereas some ...read more
Harnessing Bioactive Compounds from Food Waste: Sustainable Extraction Strategies and Health Applications
Food waste presents a significant challenge across the postharvest cycle, from agricultural production to distribution. However, within this waste lies a treasure trove of bioactive chemicals that hold immense potential for nutraceuticals, functional foods, and postharvest additives, including antimicrobials. Various extraction methods, such as solvent extraction (SE), supercritical fluid extraction ...read more
Natural Bioactive Compounds Derivatives in Nutraceutical and Food Science
In the last years, plants have been widely used for their numerous properties and now there is growing interest in the study of classes of compounds obtained from plant species or derived from them. The importance of these natural compounds lies in their important therapeutic purposes, and in their capability ...read more
Related Books
Functional Foods for Health Maintenance: Understanding their Role in Cancer Prevention
Green Extraction Techniques in Food Analysis
Algal Functional Foods and Nutraceuticals: Benefits, Opportunities, and Challenges
Micronutrients: The Key to Good Health
Capillary Electrophoresis in Food Analysis
Nutritional Biochemistry: From the Classroom to the Research Bench
Hypersensitivity to Vitamins
Foods for Special Dietary Regimens
32
2
1