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Mini-Reviews in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

Phosphonated N,O-Nucleosides: Synthesis and Biological Evaluation

Author(s): Salvatore V. Giofre, Roberto Romeo, Ugo Chiacchio, Giovanni Romeo and Maria A. Chiacchio

Volume 12, Issue 3, 2015

Page: [249 - 257] Pages: 9

DOI: 10.2174/1570193X1203150429104924

Price: $65

Abstract

The review offers an overview on the synthesis of phosphonated N,O-nucleosides, a new class of interesting, potential antiviral/ antitumor agents. The main synthetic method exploit a 1,3- dipolar cycloaddition reaction as key step. The cycloaddition process involves the use of phosphonated nitrones, or nitrones containing functional groups easily convertible into phosphonated group. Biological assays are presented, which show that phosphonated N,O-nucleosides represent a new promising template of nucleoside analogues.

Keywords: 1, 3-dipolar cycloaddition, antitumor agents, antiviral agents, biological tests, nitrones, phosphonated N, Onucleosides, synthesis.

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