Abstract
Skin delivery is more advantageous for drug administration than other routes since it is more compliant and can avoid the first-pass metabolic effect. More importantly, it can ensure stable blood level of transdermal drugs for a long period of time, avoiding fluctuation and reducing side effects. However, it is restricted by the barrier function of the stratum corneum. Therefore, significant attention has been paid to developing methods to modify the kinetics of skin drug delivery and expand the range of drugs that can be used for transdermal delivery. Novel mechanisms of increasing the intercellular and appendages penetration pathways have also been developed. This review focuses on chemical penetration enhancers, physical permeabilization (sonophoresis, iontophoresis and microneedles) and novel nanocarriers for skin delivery. Recent developments on skin delivery are also discussed.
Keywords: Chemical penetration enhancer, nanocarrier, physical permeabilization, skin barrier.
Current Pharmaceutical Design
Title:Breaking the Skin Barrier: Achievements and Future Directions
Volume: 21 Issue: 20
Author(s): Hui Zhang, Yingjie Zhai, Xiaoye Yang and Guangxi Zhai
Affiliation:
Keywords: Chemical penetration enhancer, nanocarrier, physical permeabilization, skin barrier.
Abstract: Skin delivery is more advantageous for drug administration than other routes since it is more compliant and can avoid the first-pass metabolic effect. More importantly, it can ensure stable blood level of transdermal drugs for a long period of time, avoiding fluctuation and reducing side effects. However, it is restricted by the barrier function of the stratum corneum. Therefore, significant attention has been paid to developing methods to modify the kinetics of skin drug delivery and expand the range of drugs that can be used for transdermal delivery. Novel mechanisms of increasing the intercellular and appendages penetration pathways have also been developed. This review focuses on chemical penetration enhancers, physical permeabilization (sonophoresis, iontophoresis and microneedles) and novel nanocarriers for skin delivery. Recent developments on skin delivery are also discussed.
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Cite this article as:
Zhang Hui, Zhai Yingjie, Yang Xiaoye and Zhai Guangxi, Breaking the Skin Barrier: Achievements and Future Directions, Current Pharmaceutical Design 2015; 21 (20) . https://dx.doi.org/10.2174/1381612821666150428124406
DOI https://dx.doi.org/10.2174/1381612821666150428124406 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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