Abstract
There is increasing evidence that nutritional and hormonal signals during development can influence longevity. It was reported that mice subjected to mild calorie restriction only during the preweaning period live longer than control animals. In long-lived hypopituitary dwarf mice, longevity can be reduced by growth hormone replacement therapy during pre- and peri-pubertal period. These findings suggest that trajectory of aging is importantly influenced by the availability of nutrients and the levels of anabolic hormones during development.
Keywords: Aging, longevity, calorie restriction, hypopituitary dwarf mice.
Current Aging Science
Title:Early Life Events can Shape Aging and Longevity
Volume: 8 Issue: 1
Author(s): Andrzej Bartke
Affiliation:
Keywords: Aging, longevity, calorie restriction, hypopituitary dwarf mice.
Abstract: There is increasing evidence that nutritional and hormonal signals during development can influence longevity. It was reported that mice subjected to mild calorie restriction only during the preweaning period live longer than control animals. In long-lived hypopituitary dwarf mice, longevity can be reduced by growth hormone replacement therapy during pre- and peri-pubertal period. These findings suggest that trajectory of aging is importantly influenced by the availability of nutrients and the levels of anabolic hormones during development.
Export Options
About this article
Cite this article as:
Bartke Andrzej, Early Life Events can Shape Aging and Longevity, Current Aging Science 2015; 8 (1) . https://dx.doi.org/10.2174/1874609808666150422123355
DOI https://dx.doi.org/10.2174/1874609808666150422123355 |
Print ISSN 1874-6098 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-6128 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Effects of General Anesthetics on Synaptic Transmission
Current Neuropharmacology Role of Phytomolecules in the Treatment of Obesity: Targets, Mechanisms and Limitations
Current Topics in Medicinal Chemistry Targeting IGF-I, IGFBPs and IGF-I Receptor System in Cancer: The Current and Future in Breast Cancer Therapy
Recent Patents on Anti-Cancer Drug Discovery New Potential Pharmaceutical Applications of Hypericum Species
Mini-Reviews in Medicinal Chemistry Commentary [Targeting Opioid Receptors: A New Treatment for Brain Disorders]
CNS & Neurological Disorders - Drug Targets A Predictive Model of the Prevalence of Delirium in Elderly Subjects Admitted to Nursing Homes
Endocrine, Metabolic & Immune Disorders - Drug Targets Drugs Used to Treat Parkinsons Disease, Present Status and Future Directions
CNS & Neurological Disorders - Drug Targets Development of Hypoxia Selective Cytotoxins for Cancer Treatment: An Update
Medicinal Chemistry Human Fetal Pigmented Ciliary Epithelium Stem Cells have Regenerative Capacity in the Murine Retinal Degeneration Model of Laser Injury
Current Neurovascular Research Function-Driven Discovery of Neuropeptides with Mass Spectrometry- Based Tools
Protein & Peptide Letters Recent Clinical Evidence for the Treatment of Osteoarthritis: What we have Learned
Reviews on Recent Clinical Trials Editorial [Hot Topic: Multiple Sclerosis – From Bench to Bedside (Guest Editors: Sandra Amor and David Baker)]
CNS & Neurological Disorders - Drug Targets Cytisine - From the Past to the Future
Current Pharmaceutical Design Abnormal Clock Gene Expression and Locomotor Activity Rhythms in Two Month-Old Female APPSwe/PS1dE9 Mice
Current Alzheimer Research The Protective Effect of Korean Red Ginseng Against Rotenone-Induced Parkinson’s Disease in Rat Model: Modulation of Nuclear Factor-κβ and Caspase-3
Current Pharmaceutical Biotechnology Chemotherapeutic Agents Against Malaria: What Next After Chloroquine?
Current Topics in Medicinal Chemistry Computational Chemistry Study of Natural Alkaloids and Homemade Databank to Predict Inhibitory Potential Against Key Enzymes in Neurodegenerative Diseases
Current Topics in Medicinal Chemistry Cognitive Dysfunction in Major Depressive Disorder: A State-of-the-Art Clinical Review
CNS & Neurological Disorders - Drug Targets Cardiovascular Effects of Current and Future Anti-Obesity Drugs
Current Vascular Pharmacology Fostering Resilience: Protective Agents, Resources, and Mechanisms for Adolescent Refugees' Psychosocial Well-Being
Adolescent Psychiatry