Abstract
Cardiovascular and cerebrovascular diseases (CCVD) are a major and increasing health burden worldwide. Although treatments have been made a certain progress, the development of novel therapies for patients remains a major research object. There are a lot of drugs against CCVD, but most of them lack tissue specificity with a short half-life, which seriously limits their extensive clinical application. Utilization of some pathophysiological changes caused by CCVD, targeted drug distribution in CCVD patients could be achieved. The current review aims to capture various drug delivery systems transporting drug specifically to vascular disease, including passive, active and physicochemical targeted delivery carriers. Their design strategies and mechanisms are described in detail. The present limitations and future perspective are also discussed.
Keywords: Cardiovascular and cerebrovascular diseases, pathophysiological changes, passive, active, physicochemical, targeting, drug delivery, carriers.
Current Drug Targets
Title:Targeted Drug Delivery for Cardiovascular and Cerebrovascular Diseases
Volume: 17 Issue: 4
Author(s): Jingjing Luan and Guangxi Zhai
Affiliation:
Keywords: Cardiovascular and cerebrovascular diseases, pathophysiological changes, passive, active, physicochemical, targeting, drug delivery, carriers.
Abstract: Cardiovascular and cerebrovascular diseases (CCVD) are a major and increasing health burden worldwide. Although treatments have been made a certain progress, the development of novel therapies for patients remains a major research object. There are a lot of drugs against CCVD, but most of them lack tissue specificity with a short half-life, which seriously limits their extensive clinical application. Utilization of some pathophysiological changes caused by CCVD, targeted drug distribution in CCVD patients could be achieved. The current review aims to capture various drug delivery systems transporting drug specifically to vascular disease, including passive, active and physicochemical targeted delivery carriers. Their design strategies and mechanisms are described in detail. The present limitations and future perspective are also discussed.
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Cite this article as:
Luan Jingjing and Zhai Guangxi, Targeted Drug Delivery for Cardiovascular and Cerebrovascular Diseases, Current Drug Targets 2016; 17 (4) . https://dx.doi.org/10.2174/1389450116666150416120224
DOI https://dx.doi.org/10.2174/1389450116666150416120224 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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