Abstract
An efficient, simple and environmentally benign methodology has been developed for the synthesis of 5,6-unsubstituted 1,4-dihydropyridine derivatives by a three-component condensation of β-keto esters, amines and α,β-unsaturated aldehydes under solvent-free conditions catalyzed by an aprotic imidazole-based zwitterionic salt. The key advantages of this protocol are metal-free reaction conditions, short reaction time, high yields, reusability of the catalyst, and easy work-up. A variety of dihydropyridine derivatives have been synthesized with high yields at room temperature and only water is formed as a green by-product.
Keywords: Dihydropyridines, imidazolium zwitterion, multicomponent, organocatalysis, reusability, solvent-free.
Current Organocatalysis
Title:Zwitterionic Imidazolium Salt: An Efficient Organocatalyst for the One-Pot Synthesis of 5,6-Unsubstituted 1,4-Dihydropyridine Scaffolds
Volume: 3 Issue: 2
Author(s): Avik Kumar Bagdi, Dhiman Kundu, Adinath Majee and Alakananda Hajra
Affiliation:
Keywords: Dihydropyridines, imidazolium zwitterion, multicomponent, organocatalysis, reusability, solvent-free.
Abstract: An efficient, simple and environmentally benign methodology has been developed for the synthesis of 5,6-unsubstituted 1,4-dihydropyridine derivatives by a three-component condensation of β-keto esters, amines and α,β-unsaturated aldehydes under solvent-free conditions catalyzed by an aprotic imidazole-based zwitterionic salt. The key advantages of this protocol are metal-free reaction conditions, short reaction time, high yields, reusability of the catalyst, and easy work-up. A variety of dihydropyridine derivatives have been synthesized with high yields at room temperature and only water is formed as a green by-product.
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Cite this article as:
Bagdi Kumar Avik, Kundu Dhiman, Majee Adinath and Hajra Alakananda, Zwitterionic Imidazolium Salt: An Efficient Organocatalyst for the One-Pot Synthesis of 5,6-Unsubstituted 1,4-Dihydropyridine Scaffolds, Current Organocatalysis 2016; 3 (2) . https://dx.doi.org/10.2174/2213337202666150414201734
DOI https://dx.doi.org/10.2174/2213337202666150414201734 |
Print ISSN 2213-3372 |
Publisher Name Bentham Science Publisher |
Online ISSN 2213-3380 |
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