Lipophilic Statins as Anticancer Agents: Molecular Targeted Actions and Proposal in Advanced Gynaecological Malignancies

Title:Lipophilic Statins as Anticancer Agents: Molecular Targeted Actions and Proposal in Advanced Gynaecological Malignancies

Volume: 16 Issue: 10

Author(s): Salvatore Gizzo, Michela Quaranta, Giovanni Battista Nardelli and Marco Noventa

Affiliation:

Keywords: Adjuvant treatments, advanced stages of cancer, anticancer agents, gynaecological malignancies, pleiotropic action of drugs, statin use.

Abstract: Despite adequate surgery, women affected by advanced-stage gynaecological cancers (ovarian/ endometrial malignancies) carry an extremely poor prognosis; an improved oncological prognosis could largely depend upon the enhancement of adjuvant treatment. Recent data showed that, among women affected by endometrial/ovarian malignancies, a reduced cancer-related mortality was noted in statin-users compared to non-users, suggesting the need for clinical trials to define the anticancerproperties of statins. In vitro/in vivo evidences suggest a potential chemo-preventive effect through induction of cancer-cell apoptosis and inhibition of cancer-cell growth, proliferation, invasion, and metastasis. The potential oncological impact of this discovery compels us to investigate all possible molecular targets for anticancer activities of statins in order to identify a rationale in proposing their administration in association with standard chemotherapy/radiotherapy protocols after adequate surgical-treatment for advanced-stages gynaecological malignancies.

Cite this article as:

Gizzo Salvatore, Quaranta Michela, Battista Nardelli Giovanni and Noventa Marco, Lipophilic Statins as Anticancer Agents: Molecular Targeted Actions and Proposal in Advanced Gynaecological Malignancies, Current Drug Targets 2015; 16 (10) . https://dx.doi.org/10.2174/1389450116666150330113239