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Current Radiopharmaceuticals

Editor-in-Chief

ISSN (Print): 1874-4710
ISSN (Online): 1874-4729

Hypoxia PET Tracers in EBRT Dose Planning in Head and Neck Cancer

Author(s): Marina Hodolic, Jure Fettich and Kalevi Kairemo

Volume 8, Issue 1, 2015

Page: [32 - 37] Pages: 6

DOI: 10.2174/1874471008666150316222400

Price: $65

Abstract

Over the years, external beam radiotherapy (EBRT) has been used in the treatment management of many malignancies, including head and neck squamous cell carcinomas (HNSCC). Hypoxia is a common feature in HNSCC. Hypoxic segments in HNSCC have proven to be more resistant to radiotherapy. The ability to identify hypoxia using SPECT and PET tracers has been investigated since the late 1970s. Nitroimidazole-based compounds labelled with positron emitters have been developed to more specifically image hypoxia. This article reviews the current data from research publications on18F–FMISO, 18F-FAZA, 18F-EF5 and 64Cu-ATSM.

Keywords: Head and neck cancers, hypoxia, PET/CT tracers, radiotherapy planning.

Graphical Abstract

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