Generic placeholder image

Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Animal Models of Systemic Sclerosis

Author(s): Florence Morin, Niloufar Kavian and Frederic Batteux

Volume 21, Issue 18, 2015

Page: [2365 - 2379] Pages: 15

DOI: 10.2174/1381612821666150316120338

Price: $65

Abstract

Systemic sclerosis is a systemic connective tissue disorder characterized by the fibrosis of the skin and certain visceral organs, vasculopathy, and immunological abnormalities. Several genetic and inducible animal models of SSc have been developed and are available for research studies. The purpose of this review is to summarize the various animal models of systemic sclerosis and describe the various contributions of these models in terms of understanding the pathophysiology of the condition and searching for new therapeutic strategies for this incurable disease.

Keywords: Systemic sclerosis, fibrosis, vasculopathy, auto-immunity, mice, transgenic, knock-out, topoisomerase-1.


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy