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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5230
ISSN (Online): 1875-614X

Design and Synthesis of Mannich bases as Benzimidazole Derivatives as Analgesic Agents

Author(s): Prasanna A. Datar and Saleel A. Limaye

Volume 14, Issue 1, 2015

Page: [35 - 46] Pages: 12

DOI: 10.2174/1871523014666150312164625

Price: $65

Abstract

Mannich bases were selected for 2D QSAR study to derive meaningful relationship between the structural features and analgesic activity. Using the knowledge of important features a novel series was designed to obtain improved analgesic activity. A series of novel Mannich bases 1-(N-substituted amino)methyl]-2-substituted benzimidazole derivatives were synthesized and were screened for analgesic activity. Some of these compounds showed promising analgesic activity when compared with the standard drug diclofenac sodium.

Keywords: Analgesic activity, Mannich bases, N1-substituted benzimidazoles.


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